Matches in SemOpenAlex for { <https://semopenalex.org/work/W84234433> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W84234433 abstract "The terrorist attacks with nerve agents in Japan as well as the ongoing debate on a possible relationship between the so-called Gulf War Syndrome and accidental exposure to traces of nerve agents have made clear that improved methods for detection of exposure to organophosphates are needed. Low level exposures can not be detected by the methods which, are presently available. In addition, these methods have a limited value for retrospective analysis. We developed a method for biomonitoring of human exposure based on organophosphate-inhibited butyrylcholinesterase (BuChE) as the most persistant and abundantly available marker in blood. High concentrations of fluoride ions release the organophosphate from BuChE with formation of a phosphofluoridate, which is specific for the organophosphate used except for its leaving group. The phosphofluoridate can be identified and quantitated, e.g., by means of gas chromatography, in order to determine origin and extent of poisoning. In the present work we studied during which period of time the new method can be used subsequent to sublethal exposure to tabun or sarin (1–4 μg/kg, i.v.) of atropinized rhesus monkeys, as a model for humans. It appeared that exposure could be monitored in these animals for 3–5 weeks at inhibition levels of BuChE ≥ 0.01%. In addition, a method was developed for LC-MS-MS analysis of the hydrolysis product of sarin in blood. The usefulness of the new procedures was demonstrated by our preliminary analysis of serum samples from victims of the terrorist attack in the Tokyo subway and in Matsumoto." @default.
- W84234433 created "2016-06-24" @default.
- W84234433 creator A5012054433 @default.
- W84234433 creator A5014373158 @default.
- W84234433 creator A5028643933 @default.
- W84234433 creator A5046018938 @default.
- W84234433 creator A5066436854 @default.
- W84234433 creator A5081580355 @default.
- W84234433 date "1999-01-01" @default.
- W84234433 modified "2023-09-25" @default.
- W84234433 title "Retrospective Detection of Exposure to Organophosphates: Analyses in Blood of Human Beings and Rhesus Monkeys" @default.
- W84234433 cites W1490525072 @default.
- W84234433 cites W2079938843 @default.
- W84234433 cites W2080099610 @default.
- W84234433 cites W2083258146 @default.
- W84234433 cites W2092287287 @default.
- W84234433 doi "https://doi.org/10.1007/978-94-011-4641-8_40" @default.
- W84234433 hasPublicationYear "1999" @default.
- W84234433 type Work @default.
- W84234433 sameAs 84234433 @default.
- W84234433 citedByCount "4" @default.
- W84234433 countsByYear W842344332017 @default.
- W84234433 crossrefType "book-chapter" @default.
- W84234433 hasAuthorship W84234433A5012054433 @default.
- W84234433 hasAuthorship W84234433A5014373158 @default.
- W84234433 hasAuthorship W84234433A5028643933 @default.
- W84234433 hasAuthorship W84234433A5046018938 @default.
- W84234433 hasAuthorship W84234433A5066436854 @default.
- W84234433 hasAuthorship W84234433A5081580355 @default.
- W84234433 hasConcept C161176658 @default.
- W84234433 hasConcept C181199279 @default.
- W84234433 hasConcept C185592680 @default.
- W84234433 hasConcept C2776130705 @default.
- W84234433 hasConcept C2776588719 @default.
- W84234433 hasConcept C2778706303 @default.
- W84234433 hasConcept C2778816929 @default.
- W84234433 hasConcept C2779059548 @default.
- W84234433 hasConcept C2779101902 @default.
- W84234433 hasConcept C2780266723 @default.
- W84234433 hasConcept C2780292010 @default.
- W84234433 hasConcept C31896038 @default.
- W84234433 hasConcept C33070731 @default.
- W84234433 hasConcept C55493867 @default.
- W84234433 hasConcept C6557445 @default.
- W84234433 hasConcept C71924100 @default.
- W84234433 hasConcept C86803240 @default.
- W84234433 hasConcept C98274493 @default.
- W84234433 hasConceptScore W84234433C161176658 @default.
- W84234433 hasConceptScore W84234433C181199279 @default.
- W84234433 hasConceptScore W84234433C185592680 @default.
- W84234433 hasConceptScore W84234433C2776130705 @default.
- W84234433 hasConceptScore W84234433C2776588719 @default.
- W84234433 hasConceptScore W84234433C2778706303 @default.
- W84234433 hasConceptScore W84234433C2778816929 @default.
- W84234433 hasConceptScore W84234433C2779059548 @default.
- W84234433 hasConceptScore W84234433C2779101902 @default.
- W84234433 hasConceptScore W84234433C2780266723 @default.
- W84234433 hasConceptScore W84234433C2780292010 @default.
- W84234433 hasConceptScore W84234433C31896038 @default.
- W84234433 hasConceptScore W84234433C33070731 @default.
- W84234433 hasConceptScore W84234433C55493867 @default.
- W84234433 hasConceptScore W84234433C6557445 @default.
- W84234433 hasConceptScore W84234433C71924100 @default.
- W84234433 hasConceptScore W84234433C86803240 @default.
- W84234433 hasConceptScore W84234433C98274493 @default.
- W84234433 hasLocation W842344331 @default.
- W84234433 hasOpenAccess W84234433 @default.
- W84234433 hasPrimaryLocation W842344331 @default.
- W84234433 hasRelatedWork W162766262 @default.
- W84234433 hasRelatedWork W1973085188 @default.
- W84234433 hasRelatedWork W2010070508 @default.
- W84234433 hasRelatedWork W2012145975 @default.
- W84234433 hasRelatedWork W2018338529 @default.
- W84234433 hasRelatedWork W2028854783 @default.
- W84234433 hasRelatedWork W2050443672 @default.
- W84234433 hasRelatedWork W2070624861 @default.
- W84234433 hasRelatedWork W2079938843 @default.
- W84234433 hasRelatedWork W2083547938 @default.
- W84234433 hasRelatedWork W2091258396 @default.
- W84234433 hasRelatedWork W2155338373 @default.
- W84234433 hasRelatedWork W2268406442 @default.
- W84234433 hasRelatedWork W2339407520 @default.
- W84234433 hasRelatedWork W239680841 @default.
- W84234433 hasRelatedWork W2403242061 @default.
- W84234433 hasRelatedWork W262606656 @default.
- W84234433 hasRelatedWork W2729257973 @default.
- W84234433 hasRelatedWork W2767267743 @default.
- W84234433 hasRelatedWork W283354654 @default.
- W84234433 isParatext "false" @default.
- W84234433 isRetracted "false" @default.
- W84234433 magId "84234433" @default.
- W84234433 workType "book-chapter" @default.