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• W842428570 abstract "Blood meal digestion in female mosquitoes is initiated by increased levels of protease enzymes in midgut epithelial cells that are then secreted into the midgut lumen. In Ae. aegypti, the level of early phase (1-6 hrs) and late phase (8-30 hrs) proteases increases dramatically after feeding as a result of translational and transcriptional control mechanisms, respectively. We have focused on coordinate expression of the late trypsin (LT), 5G1-14, serine collagenase-1 (SC-1), and Culex late trypsin homolog (CxLT) protease genes in the midgut of bloodand protein-fed mosquitoes because of their extremely high levels of expression. In order to identify transcription factors that might be required for coordinate expression of these four midgut protease genes in response to feeding, we selected candidate RNAi knock-down targets in the Target of Rapamycin (TOR) kinase and phosphoinositol-3 kinase (PI-3K) signaling pathways. Injections of dsRNA into Ae. aegypti females were used to decrease the expression of TOR, the TORassociated transcription factor YY1, and the forkhead box transcription factor linked to PI-3K signaling called FOXK1. Preliminary QRT-PCR data monitoring protease transcript abundance after knockdown of FOXK1 suggests that proteases transcription may be regulated by repression rather than activation. It is possible that one of these candidate transcription factors regulates all four protease genes and allows us to impede the mosquito’s ability to reproduce, thus presenting a new direction for insecticide development." @default.
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• W842428570 date "2009-05-01" @default.
• W842428570 modified "2023-09-26" @default.
• W842428570 title "Transcriptional Regulation of Midgut Protease Genes in Aedes aegypti Mosquitos" @default.
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