FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W842607788> ?p ?o ?g. }

• W842607788 endingPage "622" @default.
• W842607788 startingPage "605" @default.
• W842607788 abstract "Most kidney cancers are renal cell carcinomas (RCC). RCC lacks early warning signs and 70 % of patients with RCC develop metastases. Among them, 50 % of patients having skeletal metastases developed a dismal survival of less than 10 % at 5 years. Therefore, exploring the key driving proteins and pathways involved in RCC bone metastasis could benefit patients' therapy and prolong their survival. We examined the difference between the OS-RC-2 cells and the OS-RC-2-BM5 cells (subpopulation from OS-RC-2) of RCC with proteomics. Then we employed Western-blot, immunohistochemistry and the clinical database (oncomine) to screen and verify the key proteins and then we analyzed the functions and the related pathways of selected key proteins with system biology approaches. Our proteomic data revealed 26 significant changed spots (fold change <0.5 and >1.9, P < 0.05) between two cells. The Western blotting results validated for these identified spots were consistent with the proteomics'. From the public clinical database, 23 out of 26 proteins were connected with RCC metastases and 9 out of 23 with survival time directly (P < 0.05). Finally, only 8 out of 9 proteins had significantly positive results in tissues of RCC patients with bone metastasis compared with primary tumor (P < 0.05). System biology analyzing results showed these eight proteins mainly distributed in oxidative phosphorylation which indicates that mitochondria dysfunction played the critical role to regulate cells metastasis. Our article used a variety of experimental techniques to find eight proteins which abnormally regulated mitochondrial function to achieve a successful induction for RCC metastasis to bone." @default.
• W842607788 created "2016-06-24" @default.
• W842607788 creator A5001941774 @default.
• W842607788 creator A5011396539 @default.
• W842607788 creator A5018963859 @default.
• W842607788 creator A5021452379 @default.
• W842607788 creator A5042165224 @default.
• W842607788 creator A5071986353 @default.
• W842607788 creator A5076903478 @default.
• W842607788 date "2015-06-27" @default.
• W842607788 modified "2023-10-16" @default.
• W842607788 title "Eight proteins play critical roles in RCC with bone metastasis via mitochondrial dysfunction" @default.
• W842607788 cites W1493770437 @default.
• W842607788 cites W1963573373 @default.
• W842607788 cites W1968362482 @default.
• W842607788 cites W1978230022 @default.
• W842607788 cites W1980226438 @default.
• W842607788 cites W2013189048 @default.
• W842607788 cites W2019287405 @default.
• W842607788 cites W2024367581 @default.
• W842607788 cites W2031279996 @default.
• W842607788 cites W2037008545 @default.
• W842607788 cites W2042160423 @default.
• W842607788 cites W2043458577 @default.
• W842607788 cites W2044715574 @default.
• W842607788 cites W2044853699 @default.
• W842607788 cites W2045882027 @default.
• W842607788 cites W2047509793 @default.
• W842607788 cites W2047703254 @default.
• W842607788 cites W2053958549 @default.
• W842607788 cites W2055308573 @default.
• W842607788 cites W2056034929 @default.
• W842607788 cites W2067124266 @default.
• W842607788 cites W2067513698 @default.
• W842607788 cites W2070143299 @default.
• W842607788 cites W2077446001 @default.
• W842607788 cites W2088006216 @default.
• W842607788 cites W2088279551 @default.
• W842607788 cites W2089873655 @default.
• W842607788 cites W2090563079 @default.
• W842607788 cites W2103953491 @default.
• W842607788 cites W2104078147 @default.
• W842607788 cites W2105456967 @default.
• W842607788 cites W2108140552 @default.
• W842607788 cites W2126773395 @default.
• W842607788 cites W2129407204 @default.
• W842607788 cites W2132897834 @default.
• W842607788 cites W2133902481 @default.
• W842607788 cites W2139772062 @default.
• W842607788 cites W2151045885 @default.
• W842607788 cites W2151675588 @default.
• W842607788 cites W2151973824 @default.
• W842607788 cites W2153850374 @default.
• W842607788 cites W2163729820 @default.
• W842607788 cites W2165948908 @default.
• W842607788 cites W2195134092 @default.
• W842607788 cites W2338650191 @default.
• W842607788 cites W2739174192 @default.
• W842607788 cites W2768600953 @default.
• W842607788 cites W3104340513 @default.
• W842607788 cites W4239211914 @default.
• W842607788 cites W64227689 @default.
• W842607788 doi "https://doi.org/10.1007/s10585-015-9731-4" @default.
• W842607788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503866" @default.
• W842607788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26115722" @default.
• W842607788 hasPublicationYear "2015" @default.
• W842607788 type Work @default.
• W842607788 sameAs 842607788 @default.
• W842607788 citedByCount "16" @default.
• W842607788 countsByYear W8426077882015 @default.
• W842607788 countsByYear W8426077882016 @default.
• W842607788 countsByYear W8426077882017 @default.
• W842607788 countsByYear W8426077882018 @default.
• W842607788 countsByYear W8426077882019 @default.
• W842607788 countsByYear W8426077882020 @default.
• W842607788 countsByYear W8426077882021 @default.
• W842607788 countsByYear W8426077882022 @default.
• W842607788 countsByYear W8426077882023 @default.
• W842607788 crossrefType "journal-article" @default.
• W842607788 hasAuthorship W842607788A5001941774 @default.
• W842607788 hasAuthorship W842607788A5011396539 @default.
• W842607788 hasAuthorship W842607788A5018963859 @default.
• W842607788 hasAuthorship W842607788A5021452379 @default.
• W842607788 hasAuthorship W842607788A5042165224 @default.
• W842607788 hasAuthorship W842607788A5071986353 @default.
• W842607788 hasAuthorship W842607788A5076903478 @default.
• W842607788 hasBestOaLocation W8426077881 @default.
• W842607788 hasConcept C104317684 @default.
• W842607788 hasConcept C121608353 @default.
• W842607788 hasConcept C126322002 @default.
• W842607788 hasConcept C142724271 @default.
• W842607788 hasConcept C194409129 @default.
• W842607788 hasConcept C204232928 @default.
• W842607788 hasConcept C2776415932 @default.
• W842607788 hasConcept C2777472916 @default.
• W842607788 hasConcept C2777783956 @default.
• W842607788 hasConcept C2779013556 @default.
• W842607788 hasConcept C2780140570 @default.

• next