Matches in SemOpenAlex for { <https://semopenalex.org/work/W842935817> ?p ?o ?g. }
- W842935817 abstract "The past two decades have seen an explosive increase of obesity rates worldwide, with more than one billion adults overweight and 300 million of them obese. Obesity and its associated complications have become leading causes of morbidity and mortality in the United States and major contributing factors to the rising costs of national health care. The pathophysiology of obesity and type 2 diabetes in rodents and humans is characterized by low-grade inflammation and chronic activation of immune pathways in adipose tissue and liver. The CD40 receptor and its ligand, CD40L, initiate immune cell signaling promoting inflammation, but conflicting data on CD40L-null mice confound its role in obesity-associated insulin resistance. A clear understanding of how CD40 and its ligand communicate to regulate and sustain the inflammatory environment of obesity is lacking. Here we demonstrate that CD40 receptor deficient mice on a high-fat diet display the expected decrease in hepatic cytokine levels, but paradoxically exhibit liver steatosis, insulin resistance and glucose intolerance compared with their age-matched wildtype controls. Hyperinsulinemic-euglycemic clamp studies also demonstrated insulin resistance in glucose utilization by the CD40-null mice compared with wild-type mice. In contrast to liver, visceral adipose tissue in CD40 deficient animals harbors elevated cytokine levels and infiltration of inflammatory cells, particularly macrophages and CD8 effector T cells. In addition, ex vivo explants" @default.
- W842935817 created "2016-06-24" @default.
- W842935817 creator A5039465851 @default.
- W842935817 date "2013-01-01" @default.
- W842935817 modified "2023-10-03" @default.
- W842935817 title "Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation" @default.
- W842935817 cites W129544458 @default.
- W842935817 cites W1479920302 @default.
- W842935817 cites W1484262719 @default.
- W842935817 cites W1505106993 @default.
- W842935817 cites W1534360145 @default.
- W842935817 cites W1535035449 @default.
- W842935817 cites W1536477560 @default.
- W842935817 cites W1574487823 @default.
- W842935817 cites W1581041835 @default.
- W842935817 cites W1905082515 @default.
- W842935817 cites W1920972430 @default.
- W842935817 cites W1942668068 @default.
- W842935817 cites W1964562779 @default.
- W842935817 cites W1964607854 @default.
- W842935817 cites W1965102835 @default.
- W842935817 cites W1967248026 @default.
- W842935817 cites W1967724716 @default.
- W842935817 cites W1967850467 @default.
- W842935817 cites W1968509617 @default.
- W842935817 cites W1969702741 @default.
- W842935817 cites W1971415551 @default.
- W842935817 cites W1972050244 @default.
- W842935817 cites W1972709924 @default.
- W842935817 cites W1975388439 @default.
- W842935817 cites W1976591271 @default.
- W842935817 cites W1976962642 @default.
- W842935817 cites W1977499910 @default.
- W842935817 cites W1979122274 @default.
- W842935817 cites W1979354059 @default.
- W842935817 cites W1980087271 @default.
- W842935817 cites W1983318857 @default.
- W842935817 cites W1985236262 @default.
- W842935817 cites W1985592156 @default.
- W842935817 cites W1986938616 @default.
- W842935817 cites W1987531445 @default.
- W842935817 cites W1987907874 @default.
- W842935817 cites W1988502798 @default.
- W842935817 cites W1988826453 @default.
- W842935817 cites W1989049546 @default.
- W842935817 cites W1990251709 @default.
- W842935817 cites W1990469959 @default.
- W842935817 cites W1990908543 @default.
- W842935817 cites W1990962476 @default.
- W842935817 cites W1991688216 @default.
- W842935817 cites W1993418845 @default.
- W842935817 cites W1996510381 @default.
- W842935817 cites W1998493448 @default.
- W842935817 cites W1999342424 @default.
- W842935817 cites W2000054651 @default.
- W842935817 cites W2000545769 @default.
- W842935817 cites W2003380115 @default.
- W842935817 cites W2003460836 @default.
- W842935817 cites W2003578093 @default.
- W842935817 cites W2003659422 @default.
- W842935817 cites W2004680931 @default.
- W842935817 cites W2005881684 @default.
- W842935817 cites W2006768607 @default.
- W842935817 cites W2007078899 @default.
- W842935817 cites W2007405015 @default.
- W842935817 cites W2008194879 @default.
- W842935817 cites W2008381613 @default.
- W842935817 cites W2008869160 @default.
- W842935817 cites W2010247691 @default.
- W842935817 cites W2010447832 @default.
- W842935817 cites W2010957046 @default.
- W842935817 cites W2011210301 @default.
- W842935817 cites W2011255130 @default.
- W842935817 cites W2012037560 @default.
- W842935817 cites W2012519188 @default.
- W842935817 cites W2017221955 @default.
- W842935817 cites W2019472123 @default.
- W842935817 cites W2022405886 @default.
- W842935817 cites W2022897423 @default.
- W842935817 cites W2024378513 @default.
- W842935817 cites W2024921016 @default.
- W842935817 cites W2025152562 @default.
- W842935817 cites W2027481449 @default.
- W842935817 cites W2030364983 @default.
- W842935817 cites W2030627521 @default.
- W842935817 cites W2031084334 @default.
- W842935817 cites W2031637294 @default.
- W842935817 cites W2033133508 @default.
- W842935817 cites W2033946555 @default.
- W842935817 cites W2033996868 @default.
- W842935817 cites W2036833272 @default.
- W842935817 cites W2038018821 @default.
- W842935817 cites W2038043933 @default.
- W842935817 cites W2038460625 @default.
- W842935817 cites W2038689279 @default.
- W842935817 cites W2038961236 @default.
- W842935817 cites W2040153748 @default.
- W842935817 cites W2041510403 @default.
- W842935817 cites W2042087846 @default.
- W842935817 cites W2043106623 @default.