Matches in SemOpenAlex for { <https://semopenalex.org/work/W843111803> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W843111803 abstract "Background Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus.11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is considered a potential therapeutic target in the treatment of type 2 diabetes mellitus, while the potential mechanism is not very clearly identified. Methods In vitro cultured 3T3-L1 pre-adipocytes, prednisone and over-expressed 11β-HSD1 were used to induce insulin resistance. Type 2 diabetes mellitus mouse models were treated with 11β-HSD1 inhibitor PF00195715 and JNK inhibitor C66 by gavage, respectively. Results Stimulation of prednisone or over-expressed 11β-HSD1 significantly disturbed insulin signal pathway, decreased AKT phosphorylation and led to insulin resistance, while these effects were reversed by PF00195715 and C66. Either C66 or DN-JNK significantly attenuated the 11β-HSD1 over-expression induced insulin resistance, indicating a mediated role of JNK. Oral administration with either PF00195715 or C66 in mouse models remarkably relieved insulin resistance and type 2 diabetes mellitus. Conclusion 11β-HSD1 mediates insulin resistance and type 2 diabetes mellitus through JNK activation." @default.
- W843111803 created "2016-06-24" @default.
- W843111803 creator A5003490424 @default.
- W843111803 creator A5049093184 @default.
- W843111803 date "2015-04-01" @default.
- W843111803 modified "2023-09-27" @default.
- W843111803 title "11β‐HSD1 Mediates Insulin Resistance and Type 2 Diabetes Mellitus through JNK Activation" @default.
- W843111803 doi "https://doi.org/10.1096/fasebj.29.1_supplement.575.1" @default.
- W843111803 hasPublicationYear "2015" @default.
- W843111803 type Work @default.
- W843111803 sameAs 843111803 @default.
- W843111803 citedByCount "0" @default.
- W843111803 crossrefType "journal-article" @default.
- W843111803 hasAuthorship W843111803A5003490424 @default.
- W843111803 hasAuthorship W843111803A5049093184 @default.
- W843111803 hasConcept C126322002 @default.
- W843111803 hasConcept C134018914 @default.
- W843111803 hasConcept C166075782 @default.
- W843111803 hasConcept C181199279 @default.
- W843111803 hasConcept C2776317432 @default.
- W843111803 hasConcept C2777180221 @default.
- W843111803 hasConcept C2777391703 @default.
- W843111803 hasConcept C2779306644 @default.
- W843111803 hasConcept C2910068830 @default.
- W843111803 hasConcept C55493867 @default.
- W843111803 hasConcept C555293320 @default.
- W843111803 hasConcept C71924100 @default.
- W843111803 hasConcept C86803240 @default.
- W843111803 hasConceptScore W843111803C126322002 @default.
- W843111803 hasConceptScore W843111803C134018914 @default.
- W843111803 hasConceptScore W843111803C166075782 @default.
- W843111803 hasConceptScore W843111803C181199279 @default.
- W843111803 hasConceptScore W843111803C2776317432 @default.
- W843111803 hasConceptScore W843111803C2777180221 @default.
- W843111803 hasConceptScore W843111803C2777391703 @default.
- W843111803 hasConceptScore W843111803C2779306644 @default.
- W843111803 hasConceptScore W843111803C2910068830 @default.
- W843111803 hasConceptScore W843111803C55493867 @default.
- W843111803 hasConceptScore W843111803C555293320 @default.
- W843111803 hasConceptScore W843111803C71924100 @default.
- W843111803 hasConceptScore W843111803C86803240 @default.
- W843111803 hasIssue "S1" @default.
- W843111803 hasLocation W8431118031 @default.
- W843111803 hasOpenAccess W843111803 @default.
- W843111803 hasPrimaryLocation W8431118031 @default.
- W843111803 hasRelatedWork W138803513 @default.
- W843111803 hasRelatedWork W1986132654 @default.
- W843111803 hasRelatedWork W2010140898 @default.
- W843111803 hasRelatedWork W2010484394 @default.
- W843111803 hasRelatedWork W2032225465 @default.
- W843111803 hasRelatedWork W2056849036 @default.
- W843111803 hasRelatedWork W2082140668 @default.
- W843111803 hasRelatedWork W2151350502 @default.
- W843111803 hasRelatedWork W2410789767 @default.
- W843111803 hasRelatedWork W4234612679 @default.
- W843111803 hasVolume "29" @default.
- W843111803 isParatext "false" @default.
- W843111803 isRetracted "false" @default.
- W843111803 magId "843111803" @default.
- W843111803 workType "article" @default.