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- W84366195 endingPage "535" @default.
- W84366195 startingPage "523" @default.
- W84366195 abstract "The most deadly form of pancreatic cancer in humans is pancreatic ductal adenocarcinoma (PDAC), a malignancy that exhibits multiple molecular alterations, including a high frequency of K-ras, p53, p16, and Smad4 mutations. PDACs express many mitogenic growth factors and their tyrosine kinase receptors, resulting in excessive activation of mitogenic pathways. These cancers also express high levels of transforming growth factor-β (TGF-β) isoforms. This review focuses on the potential role of TGF-βs in PDAC, delineating the evidence for their paracrine growth-promoting properties that enhance tumor angiogenesis, and metastasis, and underscoring the important role of Smad7 in conferring a growth and survival advantage to pancreatic cancer cells by blocking autocrine growth-inhibitory pathways while promoting the expression of genes implicated in metastasis and apoptosis resistance." @default.
- W84366195 created "2016-06-24" @default.
- W84366195 creator A5052428479 @default.
- W84366195 date "2008-01-01" @default.
- W84366195 modified "2023-10-14" @default.
- W84366195 title "Aberrant Transforming Growth Factor-β Signaling in Human Pancreatic Cancer: Translational Implications" @default.
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- W84366195 doi "https://doi.org/10.1007/978-1-59745-293-9_32" @default.