Matches in SemOpenAlex for { <https://semopenalex.org/work/W8438712> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W8438712 abstract "As a consequence of the employment of platinum based cytostatic drugs in tumour diseases treatment, it became necessary not only to detect them in biological samples but also to determine and study the Pt-DNA adducts. The main of this work was to study the interactions between DNA and platinum based cytostatics (such as cisplatin and carboplatin). Primarily, we optimized the electrochemical detection of the drugs with detection limit of cisplatin 100 pM. The current accepted opinion about platinum based cytostatics mechanism of action is that the drugs induce their cytotoxic properties through binding to the nuclear DNA. Thus we followed by investigation of DNA interactions with the drugs. Due to this we have suggested a new biosensor, EDTA MT biosensor, and used cyclic voltammetry as a comparative technique. The average concentration of the drug bound to DNA was estimated as 8.1 ng of cisplatin per 500 ng of DNA by EDTA MT biosensor. It follows from the results obtained that the suggested biosensor could be a new useful tool for investigation of interaction of DNA with the drugs, because give a response only in the present of Pt(II)-DNA adduct. Acknowledgements This work was supported by grants: Liga proti rakovine and MSMT 6215712402." @default.
- W8438712 created "2016-06-24" @default.
- W8438712 creator A5009700689 @default.
- W8438712 creator A5012437538 @default.
- W8438712 creator A5018987832 @default.
- W8438712 creator A5029010301 @default.
- W8438712 creator A5029443147 @default.
- W8438712 creator A5039673922 @default.
- W8438712 creator A5049521868 @default.
- W8438712 creator A5088631999 @default.
- W8438712 date "2007-04-01" @default.
- W8438712 modified "2023-09-30" @default.
- W8438712 title "Study of nucleic acids interactions with platinum based cytostatics using biosensor" @default.
- W8438712 cites W2004590288 @default.
- W8438712 cites W2050529727 @default.
- W8438712 doi "https://doi.org/10.1096/fasebj.21.5.a262-a" @default.
- W8438712 hasPublicationYear "2007" @default.
- W8438712 type Work @default.
- W8438712 sameAs 8438712 @default.
- W8438712 citedByCount "4" @default.
- W8438712 crossrefType "journal-article" @default.
- W8438712 hasAuthorship W8438712A5009700689 @default.
- W8438712 hasAuthorship W8438712A5012437538 @default.
- W8438712 hasAuthorship W8438712A5018987832 @default.
- W8438712 hasAuthorship W8438712A5029010301 @default.
- W8438712 hasAuthorship W8438712A5029443147 @default.
- W8438712 hasAuthorship W8438712A5039673922 @default.
- W8438712 hasAuthorship W8438712A5049521868 @default.
- W8438712 hasAuthorship W8438712A5088631999 @default.
- W8438712 hasBestOaLocation W84387121 @default.
- W8438712 hasConcept C108204754 @default.
- W8438712 hasConcept C119128265 @default.
- W8438712 hasConcept C12554922 @default.
- W8438712 hasConcept C160756335 @default.
- W8438712 hasConcept C161790260 @default.
- W8438712 hasConcept C178790620 @default.
- W8438712 hasConcept C185592680 @default.
- W8438712 hasConcept C21951064 @default.
- W8438712 hasConcept C24107716 @default.
- W8438712 hasConcept C2776694085 @default.
- W8438712 hasConcept C2778239845 @default.
- W8438712 hasConcept C2780035454 @default.
- W8438712 hasConcept C2781451048 @default.
- W8438712 hasConcept C43617362 @default.
- W8438712 hasConcept C518104683 @default.
- W8438712 hasConcept C54355233 @default.
- W8438712 hasConcept C552990157 @default.
- W8438712 hasConcept C55493867 @default.
- W8438712 hasConcept C86803240 @default.
- W8438712 hasConcept C98274493 @default.
- W8438712 hasConceptScore W8438712C108204754 @default.
- W8438712 hasConceptScore W8438712C119128265 @default.
- W8438712 hasConceptScore W8438712C12554922 @default.
- W8438712 hasConceptScore W8438712C160756335 @default.
- W8438712 hasConceptScore W8438712C161790260 @default.
- W8438712 hasConceptScore W8438712C178790620 @default.
- W8438712 hasConceptScore W8438712C185592680 @default.
- W8438712 hasConceptScore W8438712C21951064 @default.
- W8438712 hasConceptScore W8438712C24107716 @default.
- W8438712 hasConceptScore W8438712C2776694085 @default.
- W8438712 hasConceptScore W8438712C2778239845 @default.
- W8438712 hasConceptScore W8438712C2780035454 @default.
- W8438712 hasConceptScore W8438712C2781451048 @default.
- W8438712 hasConceptScore W8438712C43617362 @default.
- W8438712 hasConceptScore W8438712C518104683 @default.
- W8438712 hasConceptScore W8438712C54355233 @default.
- W8438712 hasConceptScore W8438712C552990157 @default.
- W8438712 hasConceptScore W8438712C55493867 @default.
- W8438712 hasConceptScore W8438712C86803240 @default.
- W8438712 hasConceptScore W8438712C98274493 @default.
- W8438712 hasIssue "5" @default.
- W8438712 hasLocation W84387121 @default.
- W8438712 hasOpenAccess W8438712 @default.
- W8438712 hasPrimaryLocation W84387121 @default.
- W8438712 hasRelatedWork W1965889589 @default.
- W8438712 hasRelatedWork W1979926648 @default.
- W8438712 hasRelatedWork W2074051606 @default.
- W8438712 hasRelatedWork W2152264771 @default.
- W8438712 hasRelatedWork W2354160329 @default.
- W8438712 hasRelatedWork W2410580843 @default.
- W8438712 hasRelatedWork W2910347614 @default.
- W8438712 hasRelatedWork W4294585351 @default.
- W8438712 hasRelatedWork W4361810916 @default.
- W8438712 hasRelatedWork W4362420406 @default.
- W8438712 hasVolume "21" @default.
- W8438712 isParatext "false" @default.
- W8438712 isRetracted "false" @default.
- W8438712 magId "8438712" @default.
- W8438712 workType "article" @default.