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• W84392511 abstract "The pathological foundation of human prion diseases is a result of the conversion of the physiological form of prion protein (PrP(c)) to the pathological protease resistance form PrP(res). Most patients with prion disease have unknown reasons for this conversion and the subsequent development of a devastating neurodegenerative disorder. The conversion of PrP(c) to PrP(res), with resultant propagation and accumulation results in neuronal death and amyloidogenesis. However, with increasing understanding of neurodegenerative processes it appears that protein-misfolding and subsequent propagation of these rouge proteins, is a generic phenomenon shared with diseases caused by tau, α-synucleins and β-amyloid proteins. Consequently, effective anti-prion agents may have wider implications. A number of therapeutic approaches include polyanionic, polycyclic drugs such as pentosan polysulfate (PPS), which prevent the conversion of PrP(c) to PrP(res) and might also sequester and down-regulate PrP(res). Polyanionic compounds might also help to clear PrP(res). Treatments aimed at the laminin receptor, which is an important accessory molecule in the conversion of PrP(c) to PrP(res) - neuroprotection, immunotherapy, siRNA and antisense approaches have provided some experimental promise." @default.
• W84392511 created "2016-06-24" @default.
• W84392511 creator A5022224077 @default.
• W84392511 creator A5083902588 @default.
• W84392511 date "2013-09-18" @default.
• W84392511 modified "2023-09-23" @default.
• W84392511 title "Therapies for human prion diseases." @default.
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• W84392511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3783831" @default.
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• W84392511 hasPublicationYear "2013" @default.
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