Matches in SemOpenAlex for { <https://semopenalex.org/work/W84422574> ?p ?o ?g. }
- W84422574 endingPage "264" @default.
- W84422574 startingPage "257" @default.
- W84422574 abstract "Nicotine, an addictive agent in cigaret smoking, has been implicated in the etiology of pancreatitis and pancreatic carcinoma. Very little experimental data are, however, available regarding the effects of nicotine on the structural and functional changes in the exocrine pancreas. Two groups of rats divided into control and nicotine exposed were used. The animals in the nicotine group were maintained for 28 d with ad libitum water containing 0.77 mM of nicotine. At term, the animals were sacrificed, and pancreas was examined for pathological and functional changes. Nicotine induced cytoplasmic vacuolation and cellular edema in the exocrine pancreas. Plasma levels of glucose and insulin and CCK-8-stimulated amylase release in isolated acini were significantly decreased by nicotine, whereas the total cellular amylase content was significantly increased. Analysis of competitive ligand binding data on membranes from isolated acini showed that theB max andK d values for CCK receptors were not significantly changed by nicotine,p>0.05. These data indicate that a postreceptor mechanism is involved in the inhibition in stimulus-secretion coupling of enzyme secretion by nicotine. The increase in total cellular amylase content and decreased enzyme secretion by nicotine may be implicated in the induction of pancreatic pathology." @default.
- W84422574 created "2016-06-24" @default.
- W84422574 creator A5015772173 @default.
- W84422574 creator A5076042448 @default.
- W84422574 creator A5078261662 @default.
- W84422574 creator A5082611056 @default.
- W84422574 date "1995-12-01" @default.
- W84422574 modified "2023-10-15" @default.
- W84422574 title "Structural and functional changes of rat exocrine pancreas exposed to nicotine" @default.
- W84422574 cites W1554441898 @default.
- W84422574 cites W159198934 @default.
- W84422574 cites W1598998194 @default.
- W84422574 cites W1818807188 @default.
- W84422574 cites W1901990176 @default.
- W84422574 cites W1922988348 @default.
- W84422574 cites W1965954960 @default.
- W84422574 cites W1967318598 @default.
- W84422574 cites W1980817113 @default.
- W84422574 cites W1986241105 @default.
- W84422574 cites W1992864387 @default.
- W84422574 cites W1993588404 @default.
- W84422574 cites W1993792798 @default.
- W84422574 cites W2002349261 @default.
- W84422574 cites W2012720875 @default.
- W84422574 cites W2016848884 @default.
- W84422574 cites W2018299967 @default.
- W84422574 cites W2019682341 @default.
- W84422574 cites W2032973776 @default.
- W84422574 cites W2033192103 @default.
- W84422574 cites W2043431182 @default.
- W84422574 cites W2043813981 @default.
- W84422574 cites W2045837265 @default.
- W84422574 cites W2050346956 @default.
- W84422574 cites W2064042789 @default.
- W84422574 cites W2074245116 @default.
- W84422574 cites W2077125601 @default.
- W84422574 cites W2088018945 @default.
- W84422574 cites W2091407814 @default.
- W84422574 cites W2093279860 @default.
- W84422574 cites W2110535019 @default.
- W84422574 cites W2128635872 @default.
- W84422574 cites W2132018444 @default.
- W84422574 cites W2155805338 @default.
- W84422574 cites W2158817229 @default.
- W84422574 cites W2265537752 @default.
- W84422574 cites W2293385343 @default.
- W84422574 cites W2316712249 @default.
- W84422574 cites W4232777855 @default.
- W84422574 cites W4293247451 @default.
- W84422574 doi "https://doi.org/10.1007/bf02784950" @default.
- W84422574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8708398" @default.
- W84422574 hasPublicationYear "1995" @default.
- W84422574 type Work @default.
- W84422574 sameAs 84422574 @default.
- W84422574 citedByCount "42" @default.
- W84422574 countsByYear W844225742012 @default.
- W84422574 countsByYear W844225742014 @default.
- W84422574 countsByYear W844225742015 @default.
- W84422574 countsByYear W844225742016 @default.
- W84422574 countsByYear W844225742017 @default.
- W84422574 countsByYear W844225742018 @default.
- W84422574 countsByYear W844225742020 @default.
- W84422574 countsByYear W844225742022 @default.
- W84422574 countsByYear W844225742023 @default.
- W84422574 crossrefType "journal-article" @default.
- W84422574 hasAuthorship W84422574A5015772173 @default.
- W84422574 hasAuthorship W84422574A5076042448 @default.
- W84422574 hasAuthorship W84422574A5078261662 @default.
- W84422574 hasAuthorship W84422574A5082611056 @default.
- W84422574 hasConcept C126322002 @default.
- W84422574 hasConcept C134018914 @default.
- W84422574 hasConcept C170493617 @default.
- W84422574 hasConcept C170835558 @default.
- W84422574 hasConcept C181199279 @default.
- W84422574 hasConcept C185592680 @default.
- W84422574 hasConcept C2775967933 @default.
- W84422574 hasConcept C2778764654 @default.
- W84422574 hasConcept C2779547902 @default.
- W84422574 hasConcept C2910215949 @default.
- W84422574 hasConcept C49039625 @default.
- W84422574 hasConcept C55493867 @default.
- W84422574 hasConcept C71924100 @default.
- W84422574 hasConcept C86803240 @default.
- W84422574 hasConceptScore W84422574C126322002 @default.
- W84422574 hasConceptScore W84422574C134018914 @default.
- W84422574 hasConceptScore W84422574C170493617 @default.
- W84422574 hasConceptScore W84422574C170835558 @default.
- W84422574 hasConceptScore W84422574C181199279 @default.
- W84422574 hasConceptScore W84422574C185592680 @default.
- W84422574 hasConceptScore W84422574C2775967933 @default.
- W84422574 hasConceptScore W84422574C2778764654 @default.
- W84422574 hasConceptScore W84422574C2779547902 @default.
- W84422574 hasConceptScore W84422574C2910215949 @default.
- W84422574 hasConceptScore W84422574C49039625 @default.
- W84422574 hasConceptScore W84422574C55493867 @default.
- W84422574 hasConceptScore W84422574C71924100 @default.
- W84422574 hasConceptScore W84422574C86803240 @default.
- W84422574 hasIssue "3" @default.