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- W844943653 abstract "Objectives The purpose of this study was to examine the pathway of anti-allergic effects of Cheonmaec-tang (CMT). Methods We examined the cell viability, -hexosaminidase release, pro-inflammatory cytokines secretion and mRNA expressions, nuclear factor-kappa B (NF-) (p65) activation, inbibitor kappa B-alpha () degradation, and MAPKs activation in RBL-2H3 cells pre-treated by CMT of 2.0 mg/ml, 4.0 mg/ml separately. Results We observed that CMT reduced the secretion of -hexosaminidase, TNF-, IL-4 and the expression of COX-2 mRNA in RBL-2H3 cells. Furthermore, CMT inhibited the levels of activation of NF- (p65) protein, ERK MAPK, and degradation of in RBL-2H3 cells. Conclusions These results show that CMT has an anti-histamine effect and inhibitory effect of NF- (p65) through regulation of degradation. These suggest that CMT could be used as an anti-allergic medicine." @default.
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- W844943653 date "2010-01-01" @default.
- W844943653 modified "2023-10-15" @default.
- W844943653 title "Experimental Study about the Pathway of Inflammatory Allergic Reaction of Cheonmaec-tang" @default.
- W844943653 hasPublicationYear "2010" @default.
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