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- W845139600 abstract "目的 :检测miR-145在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达,并探讨其调控神经性钙黏附蛋白(neural cadherin,N-cadherin)在NSCLC侵袭转移中的作用。方法 :实时荧光定量PCR检测31例NSCLC组织中miR-145与Ncadherin的表达水平。采用脂质体法将miR-145 mimics瞬时转染至SPC-A1细胞,RT-PCR和Western blot检测N-cadherin的表达变化;Transwell实验检测转染后SPC-A1细胞的侵袭能力。结果:在NSCLC癌组织中,miR-145与N-cadherin的表达水平分别表现为显著下调和上调,且表达水平与淋巴结转移密切相关。在SPC-A1细胞中,过表达miR-145能降低N-cadherin的表达,并抑制肿瘤细胞的侵袭。结论:miR-145在NSCLC中低表达,其可能通过靶向调控N-cadherin而影响NSCLC的侵袭转移。" @default.
- W845139600 created "2016-06-24" @default.
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- W845139600 date "2015-01-01" @default.
- W845139600 modified "2023-09-23" @default.
- W845139600 title "miR-145在非小细胞肺癌中的表达及其对N-cadherin表达的调控" @default.
- W845139600 doi "https://doi.org/10.7655/nydxbns20150709" @default.
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