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• W84556570 abstract "To investigate the molecular basis of endothelial cell-specific gene expression, we have examined the DNA sequences and the cognate DNA-binding proteins that mediate transcription of the murine tie2/tek gene. Reporter transfection experiments conformed with earlier findings in transgenic mice, indicating that the upstream promoter of Tie2/Tek is capable of activating transcription in an endothelial cell-specific fashion. These experiments have also allowed the identification of a single upstream inhibitory region (region I) and two positive regulatory regions (regions U and A) in the proximal promoter. Electrophoretic mobility-shift assays have allowed further characterization of three novel DNA-binding sequences associated with these regions and have provided preliminary characterization of the protein factors binding to these elements. Two of the elements (U and A) confer increased transcription on a heterologous promoter, with element U functioning in an endothelial-cell-selective manner. By employing embryonic endothelial-like yolk sac cells in parallel with adult-derived endothelial cells, we have identified differences in functional activity and protein binding that may reflect mechanisms for specifying developmental regulation of tie2/tek expression. Further study of the DNA and protein elements characterized in these experiments is likely to provide new insight into the molecular basis of developmental- and cell-specific gene expression in the endothelium." @default.
• W84556570 created "2016-06-24" @default.
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• W84556570 date "1998-02-15" @default.
• W84556570 modified "2023-10-06" @default.
• W84556570 title "Functional analysis of the endothelial cell-specific Tie2/Tek promoter identifies unique protein-binding elements" @default.
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• W84556570 doi "https://doi.org/10.1042/bj3300335" @default.
• W84556570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1219145" @default.
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