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• W8458054 abstract "Asthma and chronic obstructive pulmonary disease (COPD) are characterized by an increased expression of the components of the inflammatory cascade. Inflammation is the central feature of both the diseases as both involve the recruitment and activation of inflammatory cells and changes in the structural cells of the lung. The increased expression of these proteins is due to enhanced gene transcription. Changes in gene transcription are regulated by transcription factors, which are proteins that bind to DNA and modulate the transcriptional apparatus. This chapter reviews the physiological functions of transcription factors and highlights their role relevant to the pathogenesis of asthma and COPD. Transcription factors regulate the expression of many genes—including inflammatory genes—thus playing a key role in the pathogenesis of asthma and COPD. The abnormal functioning of transcription factors essentially determines the disease severity and response to treatment because these factors amplify and perpetuate the inflammatory process. With recent advances and increased understanding of the transcription factors in the pathogenesis of asthma and COPD, several opportunities have been opened, thereby leading to the development of new potential anti-inflammatory drugs. The role of transcription factors and the genetic regulation of their expression are crucial aspects of research in asthma and COPD because there are critical mechanisms that regulate the expression of clinical phenotypes and their responsiveness to therapy." @default.
• W8458054 created "2016-06-24" @default.
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• W8458054 date "2002-01-01" @default.
• W8458054 modified "2023-09-27" @default.
• W8458054 title "Transcription Factors" @default.
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• W8458054 doi "https://doi.org/10.1016/b978-012079028-9/50108-3" @default.
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