FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W84592406> ?p ?o ?g. }

• W84592406 abstract "Editor,The 21st century has seen the emergence of the study of the genome (genomics) and its related disciplines, including metagenomics and transcriptomics, relating to prokaryotic, as well as eukaryotic organisms. This has largely happened due to technical developments in DNA sequencing technology, particularly with next generation sequencing (NGS). As a result, we are now beginning to read reports on the many applications of such advanced sequencing technologies in many disease and ecological states, including deep screening of the complex ecology of the human gut and other anatomical sites. Much attention has recently been focussed on advances in the knowledge of the gut microbiome, whereby this has been called “the last human organ” to be discovered and further investigated.1Several such investigations have identified the presence of lactic acid bacteria (LAB) in such niches2, 3 and other studies are beginning to link variation in lactic acid bacteria with a variety of disease states, including obesity4 and diabetes.5 For instance, some of our collaborative work with colleagues has demonstrated that DNA sequencing of the gut microflora revealed that bacterial composition of a diabetic group was different from that of a healthy group.5 In addition, Bacteroides vulgatus and the genus, Bifidobacterium, were poorly represented in the microbiota of the diabetic group, and a significant decrease was observed for Bifidobacterium by real-time PCR. Taken together, in this work we observed the characterisation of gut microbiota in diabetic patients, which suggests that the gut microbiota of diabetic patients have changes associated with occurrence and development of diabetes.With all of this exploitation the functional properties of the lactic acid bacteria in foodstuffs and the increased consumption of such probiotic products, we believed it timely to examine any potential increase in clinical infection with such organisms locally.We examined the incidence of clinically significant infections with the LAB over the first decade of the new millennium (2000-2010) at Belfast City Hospital, whereby we defined a clinically significant infection, where a LAB was the aetiological agent of an episode of bacteraemia. There were ten cases in total, which consisted of LAB belonging to three genera, namely Pediococcus (5 cases), Lactobacillus (3 cases) and Leuconostoc (2 cases). All of these genera have been used in a variety of fermented foods, although we cannot confirm that these infecting organisms came from either a fermented food or a probiotic product, as these organisms are natural inhabitants of various anatomical niches within the human host. Of these 10 cases, two cases involving Pediococcus were from patients attending the then NI Regional Cancer Centre at Belvoir Park Hospital. Previously, it has been shown that the gastrointestinal tract of patients undergoing cytotoxic chemotherapy regimens can become leaky, thus allowing the translocation of gut microflora into the circulatory system and cause bacteraemia. With regard to the antibiotic susceptibility of the 10 LAB isolates examined against the β lactams (penicillin), the macrolides (erythromycin) and the glycopeptides (vancomycin & teicoplanin), antibiotic resistance rates were 20%, 20%, 70% and 70%, respectively. One LAB isolate was multiresistant, i.e. resistant to two classes of antibiotics from three; i.e. β lactam + glycopeptides and another LAB isolate was panresistant, i.e. resistant to all three classes of antibiotics. However, even with such resistance patterns, there were alternative antibiotic management strategies for each of these isolates, namely the macrolides for the former isolate and tetracycline for the latter isolate.From these reports, although the LAB have been involved in a small number of cases of bacteraemia over a recent 10 year period, these organisms are not considered frequent causal agents of bacteraemia and are considered organisms of low pathogenicity (if any). Therefore, the benefits of their use as mediators of immunological homeostasis of the gut outweigh their risk as causal agents of bacteraemia, except, as we can see from above, in patients with an immunocompromised or immunosuppressed status, which may require further investigation.The low frequency of their aetiological involvement in clinical infection allows us to move forward with relative confidence with immunocompotent populations, relating to the novel and innovative ways we can deploy such organisms to moderate host microbiomes." @default.
• W84592406 created "2016-06-24" @default.
• W84592406 creator A5002459541 @default.
• W84592406 creator A5025366488 @default.
• W84592406 creator A5033892561 @default.
• W84592406 creator A5044968241 @default.
• W84592406 date "2014-01-01" @default.
• W84592406 modified "2023-09-23" @default.
• W84592406 title "Lactic acid bacterial infection, probiotics and gut microbiomes." @default.
• W84592406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3992098" @default.
• W84592406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24757273" @default.
• W84592406 hasPublicationYear "2014" @default.
• W84592406 type Work @default.
• W84592406 sameAs 84592406 @default.
• W84592406 citedByCount "0" @default.
• W84592406 crossrefType "posted-content" @default.
• W84592406 hasAuthorship W84592406A5002459541 @default.
• W84592406 hasAuthorship W84592406A5025366488 @default.
• W84592406 hasAuthorship W84592406A5033892561 @default.
• W84592406 hasAuthorship W84592406A5044968241 @default.
• W84592406 hasConcept C104317684 @default.
• W84592406 hasConcept C141231307 @default.
• W84592406 hasConcept C143121216 @default.
• W84592406 hasConcept C15151743 @default.
• W84592406 hasConcept C189206191 @default.
• W84592406 hasConcept C190944805 @default.
• W84592406 hasConcept C203014093 @default.
• W84592406 hasConcept C2778168646 @default.
• W84592406 hasConcept C2780206646 @default.
• W84592406 hasConcept C2780305828 @default.
• W84592406 hasConcept C51679486 @default.
• W84592406 hasConcept C523546767 @default.
• W84592406 hasConcept C539455810 @default.
• W84592406 hasConcept C54355233 @default.
• W84592406 hasConcept C552990157 @default.
• W84592406 hasConcept C60644358 @default.
• W84592406 hasConcept C70721500 @default.
• W84592406 hasConcept C86803240 @default.
• W84592406 hasConcept C89423630 @default.
• W84592406 hasConcept C91478284 @default.
• W84592406 hasConceptScore W84592406C104317684 @default.
• W84592406 hasConceptScore W84592406C141231307 @default.
• W84592406 hasConceptScore W84592406C143121216 @default.
• W84592406 hasConceptScore W84592406C15151743 @default.
• W84592406 hasConceptScore W84592406C189206191 @default.
• W84592406 hasConceptScore W84592406C190944805 @default.
• W84592406 hasConceptScore W84592406C203014093 @default.
• W84592406 hasConceptScore W84592406C2778168646 @default.
• W84592406 hasConceptScore W84592406C2780206646 @default.
• W84592406 hasConceptScore W84592406C2780305828 @default.
• W84592406 hasConceptScore W84592406C51679486 @default.
• W84592406 hasConceptScore W84592406C523546767 @default.
• W84592406 hasConceptScore W84592406C539455810 @default.
• W84592406 hasConceptScore W84592406C54355233 @default.
• W84592406 hasConceptScore W84592406C552990157 @default.
• W84592406 hasConceptScore W84592406C60644358 @default.
• W84592406 hasConceptScore W84592406C70721500 @default.
• W84592406 hasConceptScore W84592406C86803240 @default.
• W84592406 hasConceptScore W84592406C89423630 @default.
• W84592406 hasConceptScore W84592406C91478284 @default.
• W84592406 hasLocation W845924061 @default.
• W84592406 hasOpenAccess W84592406 @default.
• W84592406 hasPrimaryLocation W845924061 @default.
• W84592406 hasRelatedWork W1992579563 @default.
• W84592406 hasRelatedWork W2014547919 @default.
• W84592406 hasRelatedWork W2037374722 @default.
• W84592406 hasRelatedWork W2072706491 @default.
• W84592406 hasRelatedWork W2103397390 @default.
• W84592406 hasRelatedWork W2109212249 @default.
• W84592406 hasRelatedWork W2113203952 @default.
• W84592406 hasRelatedWork W2116431343 @default.
• W84592406 hasRelatedWork W2163619058 @default.
• W84592406 hasRelatedWork W2205866702 @default.
• W84592406 hasRelatedWork W2484995089 @default.
• W84592406 hasRelatedWork W2530792995 @default.
• W84592406 hasRelatedWork W2574157085 @default.
• W84592406 hasRelatedWork W2899197904 @default.
• W84592406 hasRelatedWork W2899564451 @default.
• W84592406 hasRelatedWork W3164829058 @default.
• W84592406 hasRelatedWork W3194499026 @default.
• W84592406 hasRelatedWork W3207744615 @default.
• W84592406 hasRelatedWork W70696947 @default.
• W84592406 hasRelatedWork W2192127111 @default.
• W84592406 isParatext "false" @default.
• W84592406 isRetracted "false" @default.
• W84592406 magId "84592406" @default.
• W84592406 workType "article" @default.