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- W8459254 abstract "Signal transduction induced by death receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily has been an area of intensive research for the past several years. The major advances arising from these studies have been the characterization of critical signal-transducing adaptor molecules and the delineation of parallel but opposing signaling pathways, some inducing apoptosis and others promoting cell survival. An imbalance in favor of either apoptosis or cell survival can have disastrous pathological consequences, including cancer, autoimmunity, or immune deficiency. Many adaptor proteins have been reported in the literature to be involved in death receptor signaling. In this chapter, we will focus on molecules whose functions have been investigated by multiple approaches, particularly gene targeting in mice and ex vivo biochemical studies. By validating or clarifying the function of each adaptor, we hope to construct a blueprint of the various signaling channels triggered by death receptors, providing a foundation for further scientific investigations and practical therapeutic designs." @default.
- W8459254 created "2016-06-24" @default.
- W8459254 creator A5023385055 @default.
- W8459254 creator A5062516508 @default.
- W8459254 date "2005-01-01" @default.
- W8459254 modified "2023-09-26" @default.
- W8459254 title "Adaptor Proteins in Death Receptor Signaling" @default.
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