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- W846827694 abstract "Objective Programmed cell death 1(PD-1) up-regulation can impair virus-specific CD8(superscript +) T-cell responses during chronic viral infection. Whether PD-1 affects virus-specific CD8(superscript +) T cells in humans with acute viral infection and the mechanism of this effect, however, remain largely undefined. This study aimed to characterize the PD-1 expression during acute hepatitis B(AHB), and further address how the PD-1 regulates antiviral immunity in acute HBV infection. Methods HBV-specific CD8(superscript +) T cells in peripheral blood from 16 HLA-A2-positive AHB patients were quantitatively analyzed and PD-1 expression on HBV specific CD8(superscript +) T cells were measured using flow cytometry. Intracellular IFN-γ staining was performed for analyses of the impact of PD-1 expression. Serum ALT levels, HBV markers and HBV-DNA levels were evaluated for each subject. Results All 16 AHB patients examined had multiple pentamer responses. PD-1 expression on HBV-specific CD8(superscript +) T cells was significantly up-regulated in the early phase of acute HBV infection. Blockade of PD-l ligation enhances the amount of IFN-γ production by HBV-specific CD8(superscript +) T cells following 6-h stimulation with cognate peptide. Conclusion PD-1/PD-L1 pathway plays a role in the regulation of the function of HBV-specific CD8(superscript +) T cells at early phase of acute HBV infection and high PD-l expression by HBV specific CD8(superscript +) T cells appear to efficiently temper liver damage." @default.
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- W846827694 date "2008-08-31" @default.
- W846827694 modified "2023-09-28" @default.
- W846827694 title "PD-1表达对急性乙型肝炎患者HBV特异性CD8(上标 +)T细胞功能的影响" @default.
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