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- W84697162 abstract "Publisher Summary This chapter deals with pathophysiological disorders of the peripheral nervous system (PNS) that are thought to underlie peripheral neuropathic pain. Central pain is also reviewed. Pain because of neuropathy needs to be distinguished from normal pain and from pain owing to inflammation of innervated tissues. In nociceptive and inflammatory pain, the neural impulses that signal pain arise from normal or sensitized sensory endings as part of the normal functioning of the pain detection system. Neuropathic pain results from abnormal neural discharge arising from locations other than the sensory ending, in a pain system that has been damaged. The chapter also reviews the main issues that are the mechanisms of this ectopic impulse generation and ways in which damage alters synaptic processing of resulting sensory signals. The difference among normal, inflammatory, and neuropathic pain can be thought of in terms of a home alarm system. Nociceptive and inflammatory pain represents the alarm sounding in response to an intruder." @default.
- W84697162 created "2016-06-24" @default.
- W84697162 creator A5089751343 @default.
- W84697162 date "2006-01-01" @default.
- W84697162 modified "2023-09-25" @default.
- W84697162 title "Chapter 19 Pathophysiology of nerve injury" @default.
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- W84697162 doi "https://doi.org/10.1016/s0072-9752(06)80023-0" @default.
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