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- W84697739 abstract "Stereoisomerism manifests itself in various forms, such as those related to enantiomers, diastereoisomers, epimers, meso- and geometrical isomers. Generally speaking, the consequences of stereoisomerism for the biological action of xenobiotics in living organisms are still difficult to predict because they are complex and of multi-factorial origin. In recent years, however, significant progress has been made in rationalization and understanding of toxicity at the molecular level. In the development of a toxic effect, nowadays the following stages are usually distinguished: (a) toxicokinetics (i.e., comprising absorption, distribution, and elimination); (b) biotransformation, either resulting in bioactivation or bioinactivation; (c) reversible or irreversible interactions with cellular or tissue components; (d) protection or repair mechanisms; and (e) the nature and extent of the toxic effect for the organism. By taking these stages into consideration and by realizing the intrinsic asymmetry of receptors, enzymes, and other types of macromolecules, which leads to the phenomenon of “chiral recognition,” rationalization of stereoselectivity in toxicity becomes more and more feasible." @default.
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- W84697739 date "2003-01-01" @default.
- W84697739 modified "2023-10-12" @default.
- W84697739 title "Stereoselective Bioactivation and Bioinactivation — Toxicological Aspects" @default.
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- W84697739 doi "https://doi.org/10.1007/978-3-642-55842-9_10" @default.
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