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- W847658753 abstract "Plants induce defense responses after perception of invading pathogens. Proteins called mitogen-activated protein kinases (MAPKS) are implicated in the complex signaling network occuring in plant immunity. However, the current knowledge of their function is still limited. The objective of my PHD was to contribute to a better understanding of their role and regulation in plant defense. First, i was involved in the deciphering of the specific and cooperative contributions of three MAPKS involved in plant immunity, namely MPK3, MPK4 and MPK6. We charcacterized several hallmarks of defense in WT and MAPK mutant plants. We showed notably that immune MAPKS are important regulators of the transcriptional reprogramming occuring during defense. Second, we applied phosphoproteomic approaches and we developed a protocol to enrich for chromatin-associated proteins which allowed identifying new phosphosites as well as proteins differentially phosphorylated during defense, notably some probable MAPKS substrates. Third, we identified several tens proteins potentially interacting with the immune MEKK1-MKK2-MPK4 module via the purification of protein complexes in vivo. Fourth, we identified diverse post-translational modification (PTMS) on each component of the MEKK1-MKK2-MPK4 module. Overall, this work revealed new functions for MAPKS in plant immunity. This work also provided new candidate MAPK substrates and suggests that the MEKK1-MKK2-MPK4 module is subjected to a highly complex regulation via multiple interacting proteins and PTMS." @default.
- W847658753 created "2016-06-24" @default.
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- W847658753 date "2014-12-03" @default.
- W847658753 modified "2023-09-23" @default.
- W847658753 title "Role and regulation of MAPKinases in pathogen-induced signaling in Arabidopsis thaliana" @default.
- W847658753 hasPublicationYear "2014" @default.
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