Matches in SemOpenAlex for { <https://semopenalex.org/work/W84782945> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W84782945 endingPage "16" @default.
- W84782945 startingPage "506" @default.
- W84782945 abstract "The virulence of Salmonella typhi is associated with the presence of the Vi antigen. Mechanisms of Vi antigen virulence were examined in vitro. The Vi antigen-containing strain Quailes was significantly (P less than 0.025) more resistant to lysis by nonimmune serum than S. typhi 0901, which does not have the Vi antigen, and resulted in less activation of complement by the alternative pathway (P less than 0.05). Human polymorphonuclear leukocytes (PMNs) ingested strain Quailes significantly (P less than 0.01) more slowly and less completely than strain 0901 as assessed by three measures of phagocytic rate. In contrast to prior reports, the Vi antigen did not prevent an oxidative burst, measured by O2- production, chemiluminescence, and O2 consumption. The extent of the oxidative burst correlated directly and closely with the rate of phagocytosis. When the rate of PMN phagocytosis for both strains was equalized by opsonizing strain 0901 with 1% and strain Quailes with a 3% concentration of serum, the PMN oxidative burst was equal. C3 binding to strain Quailes was significantly (P less than 0.005) less than to strain 0901. Hence the Vi antigen inhibited phagocytosis by preventing C3b binding and solely as a consequence of this induced a lesser PMN oxidative burst. Furthermore, strain Quailes was significantly (P less than 0.025) less susceptible to killing by H2O2 than strain 0901. To ensure that these observations were a consequence of the Vi antigen and not other strain differences, another pair of S. typhi with and without the Vi antigen were similarly compared, and the results were the same as with strains Quailes and 0901. Strains 0901 and Quailes were killed by PMNs from a patient with chronic granulomatous disease but more slowly than by normal PMNs, indicating that S. typhi is susceptible to nonoxidative killing." @default.
- W84782945 created "2016-06-24" @default.
- W84782945 creator A5026881530 @default.
- W84782945 creator A5059625679 @default.
- W84782945 date "1986-11-01" @default.
- W84782945 modified "2023-09-23" @default.
- W84782945 title "Role of the Vi antigen of Salmonella typhi in resistance to host defense in vitro." @default.
- W84782945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3021879" @default.
- W84782945 hasPublicationYear "1986" @default.
- W84782945 type Work @default.
- W84782945 sameAs 84782945 @default.
- W84782945 citedByCount "42" @default.
- W84782945 countsByYear W847829452012 @default.
- W84782945 countsByYear W847829452013 @default.
- W84782945 countsByYear W847829452014 @default.
- W84782945 countsByYear W847829452015 @default.
- W84782945 countsByYear W847829452017 @default.
- W84782945 countsByYear W847829452018 @default.
- W84782945 countsByYear W847829452019 @default.
- W84782945 countsByYear W847829452020 @default.
- W84782945 countsByYear W847829452022 @default.
- W84782945 crossrefType "journal-article" @default.
- W84782945 hasAuthorship W84782945A5026881530 @default.
- W84782945 hasAuthorship W84782945A5059625679 @default.
- W84782945 hasConcept C104317684 @default.
- W84782945 hasConcept C105702510 @default.
- W84782945 hasConcept C147483822 @default.
- W84782945 hasConcept C160448771 @default.
- W84782945 hasConcept C185592680 @default.
- W84782945 hasConcept C202751555 @default.
- W84782945 hasConcept C203014093 @default.
- W84782945 hasConcept C2778022156 @default.
- W84782945 hasConcept C2781065037 @default.
- W84782945 hasConcept C2994552716 @default.
- W84782945 hasConcept C523546767 @default.
- W84782945 hasConcept C54355233 @default.
- W84782945 hasConcept C547475151 @default.
- W84782945 hasConcept C55493867 @default.
- W84782945 hasConcept C60987743 @default.
- W84782945 hasConcept C86803240 @default.
- W84782945 hasConcept C89423630 @default.
- W84782945 hasConcept C99971728 @default.
- W84782945 hasConceptScore W84782945C104317684 @default.
- W84782945 hasConceptScore W84782945C105702510 @default.
- W84782945 hasConceptScore W84782945C147483822 @default.
- W84782945 hasConceptScore W84782945C160448771 @default.
- W84782945 hasConceptScore W84782945C185592680 @default.
- W84782945 hasConceptScore W84782945C202751555 @default.
- W84782945 hasConceptScore W84782945C203014093 @default.
- W84782945 hasConceptScore W84782945C2778022156 @default.
- W84782945 hasConceptScore W84782945C2781065037 @default.
- W84782945 hasConceptScore W84782945C2994552716 @default.
- W84782945 hasConceptScore W84782945C523546767 @default.
- W84782945 hasConceptScore W84782945C54355233 @default.
- W84782945 hasConceptScore W84782945C547475151 @default.
- W84782945 hasConceptScore W84782945C55493867 @default.
- W84782945 hasConceptScore W84782945C60987743 @default.
- W84782945 hasConceptScore W84782945C86803240 @default.
- W84782945 hasConceptScore W84782945C89423630 @default.
- W84782945 hasConceptScore W84782945C99971728 @default.
- W84782945 hasIssue "5" @default.
- W84782945 hasLocation W847829451 @default.
- W84782945 hasOpenAccess W84782945 @default.
- W84782945 hasPrimaryLocation W847829451 @default.
- W84782945 hasRelatedWork W1799115436 @default.
- W84782945 hasRelatedWork W1954475615 @default.
- W84782945 hasRelatedWork W1999410445 @default.
- W84782945 hasRelatedWork W2012437302 @default.
- W84782945 hasRelatedWork W2026378555 @default.
- W84782945 hasRelatedWork W2027500883 @default.
- W84782945 hasRelatedWork W2061508999 @default.
- W84782945 hasRelatedWork W2089927448 @default.
- W84782945 hasRelatedWork W2131785145 @default.
- W84782945 hasRelatedWork W84782945 @default.
- W84782945 hasVolume "108" @default.
- W84782945 isParatext "false" @default.
- W84782945 isRetracted "false" @default.
- W84782945 magId "84782945" @default.
- W84782945 workType "article" @default.