FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W848497247> ?p ?o ?g. }

• W848497247 endingPage "2055" @default.
• W848497247 startingPage "2048" @default.
• W848497247 abstract "Both endothelin-1 (ET-1) and cAMP are implicated for inducing insulin resistance. Since we have shown previously that there is a crosstalk between ET-1 and cAMP signaling pathways in regulating glucose uptake in 3T3-L1 adipocytes, we extended our investigation in this study on whether they may have a synergistic effect on inducing insulin resistance. Our results showed that it was indeed the case. Insulin-stimulated glucose uptake, phosphorylation of PKB, IRS-1-associated PI3K, and IRS-1 tyrosine phosphorylation were all inhibited by ET-1 and 8-bromo cAMP in a synergistic manner. IRS-1 protein levels were similarly decreased by ET-1 and 8-bromo cAMP, attributable to suppressed mRNA expression. In addition, after correction for the loss in IRS-1 protein, the inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation or IRS-1-associated PI3K was mainly caused by cAMP. Moreover, whereas IRS-2 protein levels were increased by cAMP or ET-1 plus cAMP, insulin-stimulated IRS-2-associated PI3K activities were abolished by both treatments. Furthermore, ET-1 and β-adrenergic agonists had similar synergistic inhibition on insulin-stimulated glucose uptake. In conclusion, we have shown that ET-1 and cAMP may synergistically induce insulin resistance in adipocytes via inhibiting IRS-1 expression as well as insulin-stimulated IRS-1/IRS-2 activities." @default.
• W848497247 created "2016-06-24" @default.
• W848497247 creator A5027786201 @default.
• W848497247 creator A5032443785 @default.
• W848497247 date "2015-10-01" @default.
• W848497247 modified "2023-09-24" @default.
• W848497247 title "Synergistic induction of insulin resistance by endothelin-1 and cAMP in 3T3-L1 adipocytes" @default.
• W848497247 cites W1491249957 @default.
• W848497247 cites W1585137472 @default.
• W848497247 cites W1605888812 @default.
• W848497247 cites W1849821171 @default.
• W848497247 cites W1898967942 @default.
• W848497247 cites W1965444145 @default.
• W848497247 cites W1980413473 @default.
• W848497247 cites W1980892600 @default.
• W848497247 cites W1983306990 @default.
• W848497247 cites W1984369273 @default.
• W848497247 cites W1988889506 @default.
• W848497247 cites W1989424037 @default.
• W848497247 cites W1990112639 @default.
• W848497247 cites W1994494371 @default.
• W848497247 cites W1996847194 @default.
• W848497247 cites W1998493448 @default.
• W848497247 cites W2011837005 @default.
• W848497247 cites W2025577409 @default.
• W848497247 cites W2043372493 @default.
• W848497247 cites W2043700366 @default.
• W848497247 cites W2056269293 @default.
• W848497247 cites W2057887781 @default.
• W848497247 cites W2058473208 @default.
• W848497247 cites W2060407689 @default.
• W848497247 cites W2064230518 @default.
• W848497247 cites W2065797421 @default.
• W848497247 cites W2067600161 @default.
• W848497247 cites W2068461520 @default.
• W848497247 cites W2076585242 @default.
• W848497247 cites W2078657772 @default.
• W848497247 cites W2086364753 @default.
• W848497247 cites W2086804651 @default.
• W848497247 cites W2093402941 @default.
• W848497247 cites W2100837269 @default.
• W848497247 cites W2111479443 @default.
• W848497247 cites W2112620654 @default.
• W848497247 cites W2114819729 @default.
• W848497247 cites W2124360636 @default.
• W848497247 cites W2141786368 @default.
• W848497247 cites W2148378054 @default.
• W848497247 cites W2148662420 @default.
• W848497247 cites W2152244367 @default.
• W848497247 cites W2153554962 @default.
• W848497247 cites W2156704597 @default.
• W848497247 cites W2157982064 @default.
• W848497247 cites W2160643103 @default.
• W848497247 cites W2160974089 @default.
• W848497247 cites W2162804111 @default.
• W848497247 cites W2165991181 @default.
• W848497247 cites W2283638085 @default.
• W848497247 cites W4235694770 @default.
• W848497247 doi "https://doi.org/10.1016/j.bbadis.2015.06.026" @default.
• W848497247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26143144" @default.
• W848497247 hasPublicationYear "2015" @default.
• W848497247 type Work @default.
• W848497247 sameAs 848497247 @default.
• W848497247 citedByCount "4" @default.
• W848497247 countsByYear W8484972472020 @default.
• W848497247 countsByYear W8484972472022 @default.
• W848497247 countsByYear W8484972472023 @default.
• W848497247 crossrefType "journal-article" @default.
• W848497247 hasAuthorship W848497247A5027786201 @default.
• W848497247 hasAuthorship W848497247A5032443785 @default.
• W848497247 hasConcept C112446052 @default.
• W848497247 hasConcept C11960822 @default.
• W848497247 hasConcept C126322002 @default.
• W848497247 hasConcept C134018914 @default.
• W848497247 hasConcept C185592680 @default.
• W848497247 hasConcept C185967709 @default.
• W848497247 hasConcept C2777391703 @default.
• W848497247 hasConcept C2777553839 @default.
• W848497247 hasConcept C2779306644 @default.
• W848497247 hasConcept C55493867 @default.
• W848497247 hasConcept C62478195 @default.
• W848497247 hasConcept C71924100 @default.
• W848497247 hasConcept C75217442 @default.
• W848497247 hasConcept C86554907 @default.
• W848497247 hasConcept C86803240 @default.
• W848497247 hasConceptScore W848497247C112446052 @default.
• W848497247 hasConceptScore W848497247C11960822 @default.
• W848497247 hasConceptScore W848497247C126322002 @default.
• W848497247 hasConceptScore W848497247C134018914 @default.
• W848497247 hasConceptScore W848497247C185592680 @default.
• W848497247 hasConceptScore W848497247C185967709 @default.
• W848497247 hasConceptScore W848497247C2777391703 @default.
• W848497247 hasConceptScore W848497247C2777553839 @default.
• W848497247 hasConceptScore W848497247C2779306644 @default.
• W848497247 hasConceptScore W848497247C55493867 @default.
• W848497247 hasConceptScore W848497247C62478195 @default.
• W848497247 hasConceptScore W848497247C71924100 @default.
• W848497247 hasConceptScore W848497247C75217442 @default.

• next