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- W84858144 abstract "Objective: To determine if the maintenance effectiveness and tolerabilityof aripiprazole demonstrated in a 12-week study were maintained in anextension phase (up to 26 weeks). Methods: This study was the extension of our switching study fromother antipsychotics to aripiprazole in symptomatically stable patients withschizophrenia or schizoaffective disorder. All the patients were randomly assigned to the aripiprazole group or the non-aripiprazole group. Results: At the baseline, the aripiprazole group (n=135) and the nonaripiprazole group (n=31) were comparable with respect to their meanages, gender distribution, baseline Positive and Negative Syndrome Scalescores, and Clinical Global Impression-Severity (CGI-S) scores. The study showed that the mean CGI-I score was 2.92 (95% CI: 2.72-3.12) in thearipiprazole group and 2.81 (95% CI: 2.35-3.26) in the non-aripiprazole group at 26 weeks. In the aripiprazole group, the remission rates at 12 and26 weeks were 74.8% and 72.6%, respectively, and 80.2% of the patients with remission at 12 weeks maintained their remission state until the end of the study. About one-fourth of the patients in the aripiprazole groupreported one or more spontaneous treatment-emergent adverse events, such as insomnia, headache, and nausea. Conclusion: This study suggested that most clinically stable outpatients with schizophrenia maintain their remission states after being switched toaripiprazole, without serious symptom aggravation and adverse events overa course of 26 weeks." @default.
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- W84858144 date "2014-01-01" @default.
- W84858144 modified "2023-09-23" @default.
- W84858144 title "Эффективность и переносимость арипипразола: 26-недельное исследование перевода с терапии пероральными антипсихотиками" @default.
- W84858144 hasPublicationYear "2014" @default.
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