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• W84859026 abstract "No AccessJournal of Urology1 Sep 1989Long-Term Results of Intravesical Bacillus Calmette-Guerin Therapy for Superficial Bladder Cancer Michael F. Sarosdy and Donald L. Lamm Michael F. SarosdyMichael F. Sarosdy More articles by this author and Donald L. LammDonald L. Lamm More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38865-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Between January 1978 and February 1984, 120 patients with superficial bladder tumors and/or carcinoma in situ were enrolled in previously reported therapeutic trials of bacillus Calmette-Guerin. Of all treated patients 78 per cent responded to initial therapy, with a followup of 13 to 120 months (median 67 months). Of the 18 patients who failed 10 were treated with repeat, intensified courses. Nine patients who had recurrent tumors within 3 to 30 months after initiation of bacillus Calmette-Guerin therapy (median 6 months) eventually ceased having recurrence. Status free of disease in the 9 patients ranged from 25 to 90 months since the last recurrence (median 64 months). With retreatment of some of the early failures, the initial success rate of 78 per cent was increased to 89 per cent. These data support the concept that intravesical immunotherapy with bacillus Calmette-Guerin should be repeated in patients who initially appear not to respond. The data also suggest that bacillus Calmette-Guerin induces a durable beneficial response rather than simply delays eventual tumor recurrence. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byRose A, El-Leithy T, Dorp F, Zakaria A, Eisenhardt A, Tschirdewahn S and Rübben H (2015) Mistletoe Plant Extract in Patients with Nonmuscle Invasive Bladder Cancer: Results of a Phase Ib/IIa Single Group Dose Escalation StudyJournal of Urology, VOL. 194, NO. 4, (939-943), Online publication date: 1-Oct-2015.Sengiku A, Ito M, Miyazaki Y, Sawazaki H, Takahashi T and Ogura K (2013) A Prospective Comparative Study of Intravesical Bacillus Calmette-Guérin Therapy with the Tokyo or Connaught Strain for Nonmuscle Invasive Bladder CancerJournal of Urology, VOL. 190, NO. 1, (50-54), Online publication date: 1-Jul-2013.PALOU J, LAGUNA P, MILLÁN-RODRÍGUEZ F, HALL R, SALVADOR-BAYARRI J and VICENTE-RODRÍGUEZ J (2018) CONTROL GROUP AND MAINTENANCE TREATMENT WITH BACILLUS CALMETTE-GUERIN FOR CARCINOMA IN SITU AND/OR HIGH GRADE BLADDER TUMORSJournal of Urology, VOL. 165, NO. 5, (1488-1491), Online publication date: 1-May-2001.KIM J and STEINBERG G (2018) THE LIMITS OF BACILLUS CALMETTE-GUERIN FOR CARCINOMA IN SITU OF THE BLADDERJournal of Urology, VOL. 165, NO. 3, (745-756), Online publication date: 1-Mar-2001.Gruenwald I, Stein A, Rashcovitsky R, Shifroni G and Lurie A (2018) A 12 Versus 6-Week Course of Bacillus Calmette-Guerin Prophylaxis for the Treatment of High Risk Superficial Bladder CancerJournal of Urology, VOL. 157, NO. 2, (487-491), Online publication date: 1-Feb-1997.Okamura T, Tozawa K, Yamada Y, Sakagami H, Ueda K and Kohri K (2018) Clinicopathological Evaluation of Repeated Courses of Intravesical Bacillus Calmette-Guerin Instillation for Preventing Recurrence of Initially Resistant Superficial Bladder CancerJournal of Urology, VOL. 156, NO. 3, (967-971), Online publication date: 1-Sep-1996.Rintala E, Jauhiainen K, Kaasinen E, Nurmi M and Alfthan O (2018) Alternating Mitomycin C and Bacillus Calmette-Guerin Instillation Prophylaxis For Recurrent Papillary (Stages Ta to T1) Superficial Bladder CancerJournal of Urology, VOL. 156, NO. 1, (56-60), Online publication date: 1-Jul-1996.Rintala E, Jauhiainen K, Rajala P, Ruutu M, Kaasinen E and Alfthan O (2018) Alternating Mitomycin C and Bacillus Calmette-Guerin Instillation Therapy for Carcinoma in Situ of the BladderJournal of Urology, VOL. 154, NO. 6, (2050-2053), Online publication date: 1-Dec-1995.Messing E, Young T, Hunt V, Newton M, Bram L, Vaillancourt A, Hisgen W, Greenberg E, Kuglitsch M and Wegenke J (2018) Hematuria Home Screening: Repeat Testing ResultsJournal of Urology, VOL. 154, NO. 1, (57-61), Online publication date: 1-Jul-1995.Nadler R, Catalona W, Hudson M and Ratliff T (2018) Durability of the Tumor-Free Response for Intravesical Bacillus Calmette-Guerin TherapyJournal of Urology, VOL. 152, NO. 2 Part 1, (367-373), Online publication date: 1-Aug-1994.Theuer C, Fitzgerald D and Pastan I (2018) A Recombinant form of Pseudomonas Exotoxin a Containing Transforming Growth Factor Alpha Near its Carboxyl Terminus for the Treatment of Bladder CancerJournal of Urology, VOL. 149, NO. 6, (1626-1632), Online publication date: 1-Jun-1993.Cookson M and Sarosdy M (2018) Management of Stage T1 Superficial Bladder Cancer with Intravesical Bacillus Calmette-Guerin TherapyJournal of Urology, VOL. 148, NO. 3 Part 1, (797-801), Online publication date: 1-Sep-1992.Lamm D (2018) Editorial CommentsJournal of Urology, VOL. 147, NO. 5, (1258-1258), Online publication date: 1-May-1992.Herr H (2018) Editorial CommentsJournal of Urology, VOL. 147, NO. 5, (1258-1258), Online publication date: 1-May-1992.Morales A, Nickel J and Wilson J (2018) Dose-Response of Bacillus Calmette-Guerin in the Treatment of Superficial Bladder CancerJournal of Urology, VOL. 147, NO. 5, (1256-1258), Online publication date: 1-May-1992.Sarosdy M, Lamm D, Williams R, Moon T, Flanigan R, Crawford E, Wilks N, Earhart R and Merritt J (2018) Phase 1 Trial of Oral Bropirimine in Superficial Bladder CancerJournal of Urology, VOL. 147, NO. 1, (31-33), Online publication date: 1-Jan-1992.Pagano F, Bassi P, Milani C, Meneghini A, Maruzzi D and Garbeglio A (2018) A Low Dose Bacillus Calmette-Guerin Regimen in Superficial Bladder Cancer Therapy: Is it Effective?Journal of Urology, VOL. 146, NO. 1, (32-35), Online publication date: 1-Jul-1991.Armstrong R (2018) Complications After Intravesical Instillation of Bacillus Calmette-guerin: Rhabdomyolysis and Metastatic InfectionJournal of Urology, VOL. 145, NO. 6, (1264-1266), Online publication date: 1-Jun-1991.Levi D’Ancona C, Rodrigues Netto N, Almeida Claro J and Ikari O (2018) Oral or Intravesical Bacillus Calmette-Guerin Immunoprophylaxis in Bladder CarcinomaJournal of Urology, VOL. 145, NO. 3, (498-501), Online publication date: 1-Mar-1991.Coplen D, Marcus M, Myers J, Ratliff T and Catalona W (2018) Long-Term Followup of Patients Treated With 1 or 2, 6-Week Courses of Intravesical Bacillus Calmette-Guerin: Analysis of Possible Predictors of Response Free of TumorJournal of Urology, VOL. 144, NO. 3, (652-657), Online publication date: 1-Sep-1990. Volume 142Issue 3September 1989Page: 719-722 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Michael F. Sarosdy More articles by this author Donald L. Lamm More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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