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- W84884103 abstract "This chapter discusses the meaning of cure in childhood central nervous system malignancies. Of all malignancies in childhood, the tumors of the central nervous system are second in frequency only to leukemia. The success of treatment in childhood leukemia has resulted in a correspondingly aggressive approach to CNS neoplasia in children. The burgeoning number of child neurologists, the increasing availability of sophisticated technology, and an ever expanding therapeutic armamentarium has led to more involvement of child neurologists in the management of CNS tumors and their complications. Depending upon the biological behavior of the particular tumor following surgery, craniospinal radiation is recommended with a large boost to the tumor bed. It is found that although a great deal is known about radiation biology and the effects of ionizing radiation on normal as well as abnormal tissue, radiation dosage schedules have been developed in an empirical fashion. Side-effects are not only dependent on the total dose but also on the radiation given per unit dose. It is found that because of radiation complications, it has been recommended that the amount of radiation per unit dose be reduced." @default.
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- W84884103 date "1988-01-01" @default.
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- W84884103 title "The Meaning of a Cure in Childhood Central Nervous System Malignancies" @default.
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- W84884103 doi "https://doi.org/10.1016/b978-0-409-90093-4.50021-3" @default.
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