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• W848893557 startingPage "193" @default.
• W848893557 abstract "Information on the use of N-acetylcysteine (NAC) in neuropsychiatric disorders has increased in recent publications. Although there are positive reports on the use of NAC in obsessive-compulsive and related disorders (OCRD), such data have not yet been validated. This article aims to review the research, case series and case reports that have been published about the use of NAC in OCRD. Research papers and case reports on the use of NAC in OCRD published within the last five years have been reviewed using the search engines of “Pubmed” and “Medline Central” databases. The search was performed by matching the terms “obsessive-compulsive disorder (OCD)”, “trichotillomania (TTM)”, “nail biting”, “skin picking”, “hoarding disorder”, and “body dysmorphic disorder” with “N-acetylcysteine”. The search identified 4 papers on TTM, 3 papers on nail biting behavior, 1 paper on OCD and 1 paper on skin-picking behavior. Three of these papers were doubleblind, placebo-controlled studies and four were case reports/series. The results of 2 papers out of the 7 that we reviewed showed that there was no difference between NAC and placebo, while 5 papers reported that the response to the NAC therapy was positive. We did not find any papers on the use of NAC in either hoarding disorder or body dysmorphic disorder. NAC is thought to be a promising psychopharmacologic agent in OCD, which is defined under OCRD due to its common etiology, similar clinical features and similar response to treatment, as well as in TTM, skin picking and nail biting. The effectiveness of glutamatergic modulators on repetitive behaviors or OCD has increased interest in NAC. Although there are a few studies in the area, many research projects are being planned, with some already in progress (www.clinicaltrials.gov), a fact that emphasizes the importance of NAC in OCRD treatment. NAC has been used in a broad spectrum of conditions such as paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion-induced injury of the myocardium, acute respiratory distress syndrome, bronchitis, chemotherapy intoxication and heavy metal intoxication. In recent years, there has been an increase in the number of studies exploring the use of NAC in neuropsychiatric disorders such as schizophrenia, autism, bipolar disorder and OCRD. In this review, we have seen that the results of studies assessing the efficacy of NAC in psychiatric disorders are promising; however, there is a need for further studies to evaluate its mechanism of action, appropriate dose range and duration of treatment." @default.
• W848893557 created "2016-06-24" @default.
• W848893557 creator A5034057877 @default.
• W848893557 creator A5060413952 @default.
• W848893557 creator A5067773185 @default.
• W848893557 date "2015-06-01" @default.
• W848893557 modified "2023-10-02" @default.
• W848893557 title "Use of N-acetylcysteine in Obsessive-Compulsive and Related Disorders" @default.
• W848893557 cites W1210974187 @default.
• W848893557 cites W1494273921 @default.
• W848893557 cites W1592375995 @default.
• W848893557 cites W1889428062 @default.
• W848893557 cites W1948780967 @default.
• W848893557 cites W1963479676 @default.
• W848893557 cites W1965926889 @default.
• W848893557 cites W1967292256 @default.
• W848893557 cites W1967464660 @default.
• W848893557 cites W1967842041 @default.
• W848893557 cites W1970665544 @default.
• W848893557 cites W1970774237 @default.
• W848893557 cites W1971990056 @default.
• W848893557 cites W1972662442 @default.
• W848893557 cites W1973157105 @default.
• W848893557 cites W1975146787 @default.
• W848893557 cites W1975835742 @default.
• W848893557 cites W1977083983 @default.
• W848893557 cites W1980048180 @default.
• W848893557 cites W1982538263 @default.
• W848893557 cites W1983968962 @default.
• W848893557 cites W1986106905 @default.
• W848893557 cites W1995317658 @default.
• W848893557 cites W1998622616 @default.
• W848893557 cites W1998700858 @default.
• W848893557 cites W1999663419 @default.
• W848893557 cites W2000048861 @default.
• W848893557 cites W2000825098 @default.
• W848893557 cites W2001006163 @default.
• W848893557 cites W2002375162 @default.
• W848893557 cites W2003906510 @default.
• W848893557 cites W2006561512 @default.
• W848893557 cites W2012978637 @default.
• W848893557 cites W2014111814 @default.
• W848893557 cites W2015425417 @default.
• W848893557 cites W2015835392 @default.
• W848893557 cites W2017032137 @default.
• W848893557 cites W2021547003 @default.
• W848893557 cites W2021763860 @default.
• W848893557 cites W2025201543 @default.
• W848893557 cites W2025562320 @default.
• W848893557 cites W2026977189 @default.
• W848893557 cites W2027620463 @default.
• W848893557 cites W2034698148 @default.
• W848893557 cites W2034751609 @default.
• W848893557 cites W2037027138 @default.
• W848893557 cites W2038083244 @default.
• W848893557 cites W2040483531 @default.
• W848893557 cites W2040527173 @default.
• W848893557 cites W2045185962 @default.
• W848893557 cites W2048299662 @default.
• W848893557 cites W2049011676 @default.
• W848893557 cites W2050249484 @default.
• W848893557 cites W2050746675 @default.
• W848893557 cites W2053626793 @default.
• W848893557 cites W2056828397 @default.
• W848893557 cites W2062540796 @default.
• W848893557 cites W2067851857 @default.
• W848893557 cites W2069294714 @default.
• W848893557 cites W2070680955 @default.
• W848893557 cites W2070873320 @default.
• W848893557 cites W2071185567 @default.
• W848893557 cites W2071517122 @default.
• W848893557 cites W2073656165 @default.
• W848893557 cites W2075810411 @default.
• W848893557 cites W2078377798 @default.
• W848893557 cites W2078974726 @default.
• W848893557 cites W2079613288 @default.
• W848893557 cites W2082855358 @default.
• W848893557 cites W2084714925 @default.
• W848893557 cites W2089787239 @default.
• W848893557 cites W2091360411 @default.
• W848893557 cites W2092069111 @default.
• W848893557 cites W2093212946 @default.
• W848893557 cites W2097386588 @default.
• W848893557 cites W2098730022 @default.
• W848893557 cites W2099921686 @default.
• W848893557 cites W2104962197 @default.
• W848893557 cites W2106719141 @default.
• W848893557 cites W2109329875 @default.
• W848893557 cites W2110075826 @default.
• W848893557 cites W2111396411 @default.
• W848893557 cites W2114570941 @default.
• W848893557 cites W2116003431 @default.
• W848893557 cites W2116655758 @default.
• W848893557 cites W2117064082 @default.
• W848893557 cites W2119258483 @default.
• W848893557 cites W2119624946 @default.
• W848893557 cites W2121174733 @default.
• W848893557 cites W2124107177 @default.

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