FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W84916623> ?p ?o ?g. }

• W84916623 endingPage "2159" @default.
• W84916623 startingPage "2148" @default.
• W84916623 abstract "Abstract Interleukin-11 (IL-11) is a pleiotropic growth factor with a prominent effect on megakaryopoiesis and thrombopoiesis. The receptor for IL-11 is a heterodimer of the signal transduction unit gp130 and a specific receptor component, the α-chain (IL-11Rα). Two genes potentially encode the IL-11Rα: the IL11Ra and IL11Ra2 genes. The IL11Ra gene is widely expressed in hematopoietic and other organs, whereas the IL11Ra2 gene is restricted to only some strains of mice and its expression is confined to testis, lymph node, and thymus. To investigate the essential actions mediated by the IL-11Rα, we have generated mice with a null mutation of IL11Ra (IL11Ra−/−) by gene targeting. Analysis of IL11Ra expression by Northern blot and reverse transcriptase-polymerase chain reaction, as well as the absence of response of IL11Ra−/− bone marrow cells to IL-11 in hematopoietic assays, further confirmed the null mutation. Compensatory expression of the IL11Ra2 in bone marrow cells was not detected. IL11Ra−/− mice were healthy with normal numbers of peripheral blood white blood cells, hematocrit, and platelets. Bone marrow and spleen contained normal numbers of cells of all hematopoietic lineages, including megakaryocytes. Clonal cultures did not identify any perturbation of granulocyte-macrophage (GM), erythroid, or megakaryocyte progenitors. The number of day-12 colony-forming unit-spleen progenitors were similar in wild-type and IL11Ra−/− mice. The kinetics of recovery of peripheral blood white blood cells, platelets, and bone marrow GM progenitors after treatment with 5-flurouracil were the same in IL11Ra−/− and wild-type mice. Acute hemolytic stress was induced by phenylhydrazine and resulted in a 50% decrease in hematocrit. The recovery of hematocrit was comparable in IL11Ra−/− and wild-type mice. These observations indicate that IL-11 receptor signalling is dispensable for adult hematopoiesis." @default.
• W84916623 created "2016-06-24" @default.
• W84916623 creator A5000500489 @default.
• W84916623 creator A5002938385 @default.
• W84916623 creator A5016659008 @default.
• W84916623 creator A5020490438 @default.
• W84916623 creator A5060163580 @default.
• W84916623 creator A5077980431 @default.
• W84916623 date "1997-09-15" @default.
• W84916623 modified "2023-10-16" @default.
• W84916623 title "Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis" @default.
• W84916623 cites W122122989 @default.
• W84916623 cites W1488696575 @default.
• W84916623 cites W1547038479 @default.
• W84916623 cites W1582172850 @default.
• W84916623 cites W1583308104 @default.
• W84916623 cites W189385581 @default.
• W84916623 cites W193519295 @default.
• W84916623 cites W1981391883 @default.
• W84916623 cites W1981892481 @default.
• W84916623 cites W1985262279 @default.
• W84916623 cites W1986605550 @default.
• W84916623 cites W1988152117 @default.
• W84916623 cites W1991055608 @default.
• W84916623 cites W1991997127 @default.
• W84916623 cites W1992396464 @default.
• W84916623 cites W1992490180 @default.
• W84916623 cites W2010348699 @default.
• W84916623 cites W2010576286 @default.
• W84916623 cites W2011722739 @default.
• W84916623 cites W2011936485 @default.
• W84916623 cites W2025576061 @default.
• W84916623 cites W2030697288 @default.
• W84916623 cites W2031179453 @default.
• W84916623 cites W2032592355 @default.
• W84916623 cites W2040857340 @default.
• W84916623 cites W2043222621 @default.
• W84916623 cites W2045733786 @default.
• W84916623 cites W2049651574 @default.
• W84916623 cites W2052068396 @default.
• W84916623 cites W2054165035 @default.
• W84916623 cites W2055755865 @default.
• W84916623 cites W2066790739 @default.
• W84916623 cites W2074749955 @default.
• W84916623 cites W2085451664 @default.
• W84916623 cites W2096589599 @default.
• W84916623 cites W2100314915 @default.
• W84916623 cites W2103478108 @default.
• W84916623 cites W2106432805 @default.
• W84916623 cites W2117106626 @default.
• W84916623 cites W2118024162 @default.
• W84916623 cites W2124113701 @default.
• W84916623 cites W2157895648 @default.
• W84916623 cites W2165835604 @default.
• W84916623 cites W2184561450 @default.
• W84916623 cites W2230842386 @default.
• W84916623 cites W2260013429 @default.
• W84916623 cites W2266255187 @default.
• W84916623 cites W2298463596 @default.
• W84916623 cites W2337839049 @default.
• W84916623 cites W2344615469 @default.
• W84916623 cites W2404888684 @default.
• W84916623 cites W2405920813 @default.
• W84916623 cites W2413036373 @default.
• W84916623 cites W2414424032 @default.
• W84916623 cites W2417585448 @default.
• W84916623 cites W273564206 @default.
• W84916623 cites W280510079 @default.
• W84916623 cites W4234875791 @default.
• W84916623 cites W4242225414 @default.
• W84916623 cites W4245868295 @default.
• W84916623 cites W4246794378 @default.
• W84916623 cites W4251674841 @default.
• W84916623 cites W4252030004 @default.
• W84916623 cites W4254262506 @default.
• W84916623 doi "https://doi.org/10.1182/blood.v90.6.2148" @default.
• W84916623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9310465" @default.
• W84916623 hasPublicationYear "1997" @default.
• W84916623 type Work @default.
• W84916623 sameAs 84916623 @default.
• W84916623 citedByCount "146" @default.
• W84916623 countsByYear W849166232012 @default.
• W84916623 countsByYear W849166232013 @default.
• W84916623 countsByYear W849166232014 @default.
• W84916623 countsByYear W849166232015 @default.
• W84916623 countsByYear W849166232016 @default.
• W84916623 countsByYear W849166232017 @default.
• W84916623 countsByYear W849166232018 @default.
• W84916623 countsByYear W849166232019 @default.
• W84916623 countsByYear W849166232020 @default.
• W84916623 countsByYear W849166232021 @default.
• W84916623 countsByYear W849166232022 @default.
• W84916623 countsByYear W849166232023 @default.
• W84916623 crossrefType "journal-article" @default.
• W84916623 hasAuthorship W84916623A5000500489 @default.
• W84916623 hasAuthorship W84916623A5002938385 @default.
• W84916623 hasAuthorship W84916623A5016659008 @default.
• W84916623 hasAuthorship W84916623A5020490438 @default.

• next