Matches in SemOpenAlex for { <https://semopenalex.org/work/W84981800> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W84981800 endingPage "147.23" @default.
- W84981800 startingPage "147.23" @default.
- W84981800 abstract "Abstract Previous research has shown that human dendritic cells (DC) can promote activation of natural killer cells (NK), including IFN-γ secretion and enhanced expression of activation markers. However, our recent research suggests that the heterogeneity of individual human donors determines the effect of DC on NK. In our experiments, DC, generated from peripheral blood monocytes and matured by LPS, were co-cultured with autologous NK cells purified from peripheral blood for 24 hours. In the 31 samples, only two donors’ mature DC significantly promoted the secretion of IFN-γ by NK. DC from an additional ten donors promoted the secretion of IFN-γ in the presence of a very low dosage IL-2 or IL-15 which by themselves had no effect. However, all DC could increase expression of CD69 on NK to varying degrees. Further, the DC, not the NK cells, were the key factor for increased IFN-γ secretion because those DC with higher ability to activate autologous NK could also activate allogeneic NK which had otherwise failed to be stimulated with their own autologous DC. Moreover, our current samples did not suggest that the age of the donor was significant for the interaction of NK and DC. Since both NK and DC are very important in infectious disease and cancer immunology, the heterogeneity of NK and DC crosstalk might be related to the susceptibility of some individuals to infection and cancer. However, the mechanisms that determine the effect of DC on NK activation remain to be investigated." @default.
- W84981800 created "2016-06-24" @default.
- W84981800 creator A5040129865 @default.
- W84981800 creator A5042673471 @default.
- W84981800 creator A5059983886 @default.
- W84981800 creator A5069849278 @default.
- W84981800 date "2011-04-01" @default.
- W84981800 modified "2023-09-25" @default.
- W84981800 title "Individual heterogeneity determines the interaction between human dendritic cells and natural killer cells (147.23)" @default.
- W84981800 doi "https://doi.org/10.4049/jimmunol.186.supp.147.23" @default.
- W84981800 hasPublicationYear "2011" @default.
- W84981800 type Work @default.
- W84981800 sameAs 84981800 @default.
- W84981800 citedByCount "0" @default.
- W84981800 crossrefType "journal-article" @default.
- W84981800 hasAuthorship W84981800A5040129865 @default.
- W84981800 hasAuthorship W84981800A5042673471 @default.
- W84981800 hasAuthorship W84981800A5059983886 @default.
- W84981800 hasAuthorship W84981800A5069849278 @default.
- W84981800 hasConcept C109316439 @default.
- W84981800 hasConcept C120665830 @default.
- W84981800 hasConcept C121332964 @default.
- W84981800 hasConcept C134018914 @default.
- W84981800 hasConcept C149532602 @default.
- W84981800 hasConcept C154317977 @default.
- W84981800 hasConcept C169822122 @default.
- W84981800 hasConcept C202751555 @default.
- W84981800 hasConcept C203014093 @default.
- W84981800 hasConcept C2778102761 @default.
- W84981800 hasConcept C2778170410 @default.
- W84981800 hasConcept C49039625 @default.
- W84981800 hasConcept C55493867 @default.
- W84981800 hasConcept C86803240 @default.
- W84981800 hasConcept C8891405 @default.
- W84981800 hasConcept C95444343 @default.
- W84981800 hasConceptScore W84981800C109316439 @default.
- W84981800 hasConceptScore W84981800C120665830 @default.
- W84981800 hasConceptScore W84981800C121332964 @default.
- W84981800 hasConceptScore W84981800C134018914 @default.
- W84981800 hasConceptScore W84981800C149532602 @default.
- W84981800 hasConceptScore W84981800C154317977 @default.
- W84981800 hasConceptScore W84981800C169822122 @default.
- W84981800 hasConceptScore W84981800C202751555 @default.
- W84981800 hasConceptScore W84981800C203014093 @default.
- W84981800 hasConceptScore W84981800C2778102761 @default.
- W84981800 hasConceptScore W84981800C2778170410 @default.
- W84981800 hasConceptScore W84981800C49039625 @default.
- W84981800 hasConceptScore W84981800C55493867 @default.
- W84981800 hasConceptScore W84981800C86803240 @default.
- W84981800 hasConceptScore W84981800C8891405 @default.
- W84981800 hasConceptScore W84981800C95444343 @default.
- W84981800 hasIssue "1_Supplement" @default.
- W84981800 hasLocation W849818001 @default.
- W84981800 hasOpenAccess W84981800 @default.
- W84981800 hasPrimaryLocation W849818001 @default.
- W84981800 hasRelatedWork W1977740621 @default.
- W84981800 hasRelatedWork W1986710133 @default.
- W84981800 hasRelatedWork W2034372373 @default.
- W84981800 hasRelatedWork W2088665791 @default.
- W84981800 hasRelatedWork W2115037567 @default.
- W84981800 hasRelatedWork W2140647949 @default.
- W84981800 hasRelatedWork W2263355526 @default.
- W84981800 hasRelatedWork W2322981117 @default.
- W84981800 hasRelatedWork W2375999619 @default.
- W84981800 hasRelatedWork W4305014055 @default.
- W84981800 hasVolume "186" @default.
- W84981800 isParatext "false" @default.
- W84981800 isRetracted "false" @default.
- W84981800 magId "84981800" @default.
- W84981800 workType "article" @default.