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- W85030449 abstract "Objective: Sildenafil is a selective inhibitor of cGMP spesificphosphodiesterase type 5 which is the main isoenzyme responsibleto metabolizing cyclic GMP in the penil corpus cavernosum.Sexual side effects are frequent, causing poor complianceand recently being considered effects of antidepressanttreatment. In the present study, it was aimed to evaluate theefficacy of sildenafil on antidepressant induced erectile dysfunction.Method: Of twenty seven male patients who had applied toPsychiatry Department of F?at University Medical Faculty andbeen started on antidepressant drugs for any indication andexperienced erectile dysfunction between October-August2000, 18 who had not contraindication and accepted to studywere included to this study. Sildenafil was started at 25 mg doseand increased to 50 and 100 mg doses. Erectile dysfunctionbefore treatment and each dose was assessed by TheInternational Index of Erectile Function (IIEF).Results: Of the patients, 14 (77.8%) improved. The mostfrequent side effects were flushing (n=3) and headache (n=2).Discussion: Our results demonstrate sildenafil to be efficaciousand reliable in the treatment of erectile dysfunction." @default.
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- W85030449 date "2001-01-01" @default.
- W85030449 modified "2023-09-23" @default.
- W85030449 title "Sildenafil use in antidepressant drug induced erectile dysfunction" @default.
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