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• W85040010 abstract "Uveal melanoma is the most common primary adult ocular tumor. Approximately 1500 cases are diagnosed annually in the United States. Men and women are affected in equal proportions. Uveal melanomas are much less common than cutaneous melanomas and infrequently occur in blacks. Historically, treatment was by enucleation, which provided a histological diagnosis and effective tumor treatment. These benefits, however, were obtained at the cost of immediate visual loss. The diagnostic accuracy of current noninvasive techniques (indirect ophthalmoscopy, fundus photography, fluorescein angiography, and ultrasonography) is sufficiently high that treatment decisions can routinely be based on clinical evaluation only. In 1532 eyes with a clinical diagnosis of choroidal melanoma enucleated in a multi-institutional study, an independent review of the histology by three independent ophthalmic pathologists confirmed the diagnosis in 99.7% (1527 eyes). Four of the five patients with a false-positive clinical diagnosis of melanoma had metastatic adenocarcinoma, while the fifth had a hemangioma.57 Recently, an analysis of tumor location with respect to retinal topography and light dose distribution on the retinal sphere was reported, based on the study of 420 Massachusetts residents diagnosed between 1984 and 1993 in whom fundus drawings or photographs were available for review. The results suggested that tumor initiation occurred nonuniformly: tumors were concentrated in the macular area and decreased monotonically with distance from the macula to the ciliary body. This pattern correlated positively with the dose distribution of solar light on the retinal sphere.39 An epidemiologic case-control study had suggested that sunlight exposure to the retina might be related to the development of uveal melanomas, 51 although that suggestion has been questioned.15 A recent review has discussed the nature of uveal melanoma and its possible causes and treatment.1" @default.
• W85040010 created "2016-06-24" @default.
• W85040010 creator A5017933458 @default.
• W85040010 date "2001-04-01" @default.
• W85040010 modified "2023-09-28" @default.
• W85040010 title "UVEAL MELANOMAS" @default.
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• W85040010 doi "https://doi.org/10.1016/s0889-8588(05)70219-7" @default.
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