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- W850664744 abstract "Introduction: Proper matching of ventilation (V) and pulmonary perfusion (Q) is essential for efficient gas exchange. Moreover, mismatches between V and Q and spatial heterogeneity in the V/Q ratio are hallmarks of virtually all pulmonary diseases. Unfortunately, currently available methods of imaging V and Q in small animals: 1) lack 3D resolution, which is needed to measure V/Q heterogeneity; 2) employ multiple modalities or contrast agents, which complicates data quantification; or 3) require hour-long image acquisitions, which prevent monitoring acute changes in V/Q. Potentially, these problems can be avoided using hyperpolarized (HP) Xe, which can generate lung images that reflect either ventilation or perfusion if delivered via the vasculature [1]. To exploit these unique properties, we previously introduced a method of continuously infusing Xe to the blood using an extracorporeal (EC) circuit [2]. Here we demonstrate that EC infusion can be used to generate 3D images of pulmonary perfusion." @default.
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- W850664744 date "2011-05-01" @default.
- W850664744 modified "2023-09-25" @default.
- W850664744 title "3D imaging of pulmonary ventilation and perfusion in rats using hyperpolarized 129Xe" @default.
- W850664744 hasPublicationYear "2011" @default.
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