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- W851130014 abstract "Nisoldipine is a new 1,4-dihydropyridine derivative with a potent vasodilatory and anti-ischemic effect [1–6]. Similar to nifedipine nisoldipine it preferentially binds to the inactivated calcium channel and inhibits transmembrane calcium entry [6]. From this results a negative inotropic action which is, however, 100–1000 times lower in nisoldipine than in nifedipine [6]. In in vitro experiments the duration of inhibition of vascular contractions is nearly three times longer for nisoldipine than that of nifedipine [6]. Nisoldipine shows a 100-times higher vascular selectivity than nifedipine [5, 6]. Therefore, nisoldipine seems to be preferentially suited for the treatment of hypertension and CHD, especially that of vasospastic origin [1–4]." @default.
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- W851130014 date "1989-01-01" @default.
- W851130014 modified "2023-09-26" @default.
- W851130014 title "Anti-ischemic therapy with nisoldipine" @default.
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- W851130014 doi "https://doi.org/10.1007/978-3-662-09434-1_20" @default.
- W851130014 hasPublicationYear "1989" @default.
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