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- W8514342 endingPage "182" @default.
- W8514342 startingPage "157" @default.
- W8514342 abstract "Leukemias are cancers of the hematopoietic system. Like all cancers, several genetic and epigenetic events aid in the transition from normal to malignant cell. These usually, if not always, include at least: 1) avoidance of programmed cell death from intrinsic signals; 2) acquisition of poorly regulated or unregulated self-renewal capacity; 3) prevention of critical telomere shortening; 4) inhibition of differentiation to an increasing degree as the malignancy progresses; and 5) avoidance of innate and adaptive immune responses that cause the death and/or phagocytosis of tumor cells. Many of these processes are properties of the hematopoietic stem cell (HSC) and are highly regulated, yet the hallmark populations in the most advanced leukemias, e.g., the expanded population of leukemic blasts, are not HSC. The phenotypic identity of the leukemic stem cells (LSC), i.e., the only cells within the leukemia capable of propagating the disease, has not been clearly elucidated. In this speculative review, we have two goals: to discuss the stage of hematopoietic differentiation in which LSC reside, and to begin to understand how recurrent genetic changes, including translocations and inversions, and epigenetic changes, resulting in increased or decreased expression of selected genes, play roles in the above described behaviors of leukemia cells." @default.
- W8514342 created "2016-06-24" @default.
- W8514342 creator A5016128169 @default.
- W8514342 creator A5030193536 @default.
- W8514342 creator A5082894731 @default.
- W8514342 date "2004-01-01" @default.
- W8514342 modified "2023-09-27" @default.
- W8514342 title "Leukemia and Leukemic Stem Cells" @default.
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