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- W8515089 startingPage "54" @default.
- W8515089 abstract "Miniaturized continuous-flow systems promise to transform classical batch-wise laboratory procedures into compact integrated systems providing new understanding of fundamental chemical processes as well as rapid, continuous discovery and development of new products with less use of resources and waste generation. Flow systems combine small channels, chemical-synthesis-on-a chip, and continuous separation to enable multiple synthesis and separation steps. Synthesis applications are enhanced by automated optimization as well as mechanistic and kinetic information gained from integrating reaction components with sensors, actuators, and automated fluid handling. Moreover, flow systems allow experiments on well-defined samples at conditions not easily accessed by conventional batch systems, such as reaction at high pressure and temperatures. The characteristics and capabilities of flow systems are demonstrated with case studies drawn from single transformations and multistep chemical synthesis relevant to fine chemicals and pharmaceuticals. Emphasis is placed on applications that are enabled by flow systems and are difficult to perform by conventional techniques. Scaling of the techniques to production amounts is also touched on." @default.
- W8515089 created "2016-06-24" @default.
- W8515089 creator A5001903834 @default.
- W8515089 creator A5010612132 @default.
- W8515089 creator A5071010920 @default.
- W8515089 date "2014-01-01" @default.
- W8515089 modified "2023-10-01" @default.
- W8515089 title "9.03 Organic Synthesis in Small Scale Continuous Flow: Flow Chemistry" @default.
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