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- W85190950 abstract "This chapter reviews the results that highlight three aspects of recent studies on the biology of the neurotrophins and ciliary neurotrophic factor (CNTF) — (1) the specificity of NT-3 for proprioceptive spinal sensory neurons in vitro and in vivo; (2) synergy among neurotrophic factors from different families — synergistic actions of brain-derived neurotrophic factor (BDNF) and CNTF toward motor neurons in vitro and in vivo; and (3) autocrine function of neurotrophins — evidence that endogenously derived BDNF acts in an autocrine manner to sustain the survival of adult sensory neurons. The notion of absolute dependence of developing neurons on target-derived factors remains an attractive hypothesis, in that it provides a mechanism to explain the selection or pruning process of nervous system development in which the exact number of required neurons is culled from an initial excess pool of neuroblasts. The fact that dislocation of neurons from their targets in the early postnatal stage leads to massive loss of either sensory or motor neurons suggests that target dependence continues after selection and during maturation. Once neuronal pruning and maturation have been achieved through target-derived signals, it would seem prudent that neuronal survival no longer be dictated by a frequently distant target to eliminate the risk that either target or axonal injury would invariably be fatal to a neuron. The fact that there is no evidence of nerve growth factor synthesis in adult DRG neurons suggests that the target-derived factor that supports survival of a particular neuronal subpopulation during development is likely to be different from the factor that sustains survival of these neurons via an autocrine mechanism in the adult." @default.
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- W85190950 date "1995-01-01" @default.
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- W85190950 title "Specificity, Synergy and Autocrine Roles of the Neurotrophins and CNTF" @default.
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- W85190950 doi "https://doi.org/10.1016/b978-0-08-042527-6.50029-8" @default.
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