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- W852029580 abstract "In humans among the 17 DNA polymerases identified only five are dedicated to normal DNA replication, and more than 12 are specialized DNA polymerases that are involved in repair and translesion DNA synthesis (TLS). The specialized DNA polymerases are mainly belong to the X and Y families, but a few are in the A and B families and homologous to high-fidelity replicases. In this talk, I will give examples of DNA polymerases in different structural families that bypass DNA lesions by different mechanisms. For example, human DNA pol eta is essential for UV survival. Deficiency of DNA pol h causes the variant form of Xeroderma Pigmentosum (XPV), characterized by sunlight-induced pigmentation changes and a highly elevated incidence of skin malignancies. DNA pol z is a B-family member like E. coli DNA pol II, but it is essential for primer extension in translesion synthesis of a variety of DNA lesions. DNA pol n is an A-family member and another TLS polymerase. These specialized polymerases appear to use different mechanisms to avoid “road blocks” and carry out translesion DNA synthesis. I will present our most recent results on discerning different mechanisms of TLS essential for cell survival." @default.
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- W852029580 date "2015-04-01" @default.
- W852029580 modified "2023-09-23" @default.
- W852029580 title "Mechanisms for Translesion DNA Synthesis" @default.
- W852029580 doi "https://doi.org/10.1096/fasebj.29.1_supplement.108.1" @default.
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