FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W852169817> ?p ?o ?g. }

• W852169817 abstract "The thyroid hormone receptor (TR) alters gene transcription in response to thyroid hormone (T3). Our prior studies demonstrated that dominant negative variants, including the retroviral oncoprotein v-ErbA, mislocalize to the cytoplasm and sequester TR in foci suggestive of aggresomes. Formation of the aggresome is a cellular response to the accumulation of misfolded protein aggregates for turnover. Starting as mini-aggregates, they are transported along microtubule tracks to the microtubule organizing center (MTOC), where they disrupt vimentin intermediate filaments and recruit machinery for protein degradation. Viral particles also follow the same aggresomal pathway to facilitate replication and assembly. To test for association with aggresomes, HeLa cells were cotransfected with the aggresomal markers GFP-250 and GFP-170 and DsRed2-tagged v-ErbA. There was a strong colocalization between the aggresomal markers and v-ErbA, suggesting that they are both targeted to the same subcellular location. v-ErbA foci disrupt vimentin, further demonstrating their aggresome-like properties. Proteasome inhibition is known to induce aggresome formation; thus, the effect of treatment of v-ErbA-expressing cells with the proteasome inhibitor MG132 was assessed. Upon treatment, there was a significant increase in foci size. Additionally, treatment with the microtubule-disrupting drug nocodazole inhibited aggresome formation. Taken together, these studies provide evidence for targeting of the oncoprotein v-ErbA to aggresomes, which is most likely a mechanism for its turnover." @default.
• W852169817 created "2016-06-24" @default.
• W852169817 creator A5020476147 @default.
• W852169817 date "2008-05-07" @default.
• W852169817 modified "2023-09-27" @default.
• W852169817 title "Targeting of Thyroid Hormone Receptor Variants to Aggresomes" @default.
• W852169817 cites W135471365 @default.
• W852169817 cites W1620862744 @default.
• W852169817 cites W1923091024 @default.
• W852169817 cites W1966099522 @default.
• W852169817 cites W1973963032 @default.
• W852169817 cites W1982442386 @default.
• W852169817 cites W1985113878 @default.
• W852169817 cites W1990616748 @default.
• W852169817 cites W1994817218 @default.
• W852169817 cites W2002475826 @default.
• W852169817 cites W2002559713 @default.
• W852169817 cites W2009125409 @default.
• W852169817 cites W2013569307 @default.
• W852169817 cites W2014300038 @default.
• W852169817 cites W2025922492 @default.
• W852169817 cites W2026295108 @default.
• W852169817 cites W2040253875 @default.
• W852169817 cites W2041598330 @default.
• W852169817 cites W2062441923 @default.
• W852169817 cites W2068213179 @default.
• W852169817 cites W2073681698 @default.
• W852169817 cites W2073687064 @default.
• W852169817 cites W2074314807 @default.
• W852169817 cites W2077430113 @default.
• W852169817 cites W2086526874 @default.
• W852169817 cites W2093074547 @default.
• W852169817 cites W2099001854 @default.
• W852169817 cites W2104651157 @default.
• W852169817 cites W2106200048 @default.
• W852169817 cites W2107913200 @default.
• W852169817 cites W2114261502 @default.
• W852169817 cites W2114873132 @default.
• W852169817 cites W2127068865 @default.
• W852169817 cites W2137712910 @default.
• W852169817 cites W2141992490 @default.
• W852169817 cites W2142125979 @default.
• W852169817 cites W2143676396 @default.
• W852169817 cites W2149761960 @default.
• W852169817 cites W2153703070 @default.
• W852169817 cites W2156520020 @default.
• W852169817 cites W2161807104 @default.
• W852169817 cites W2164065816 @default.
• W852169817 cites W2165684456 @default.
• W852169817 cites W2168637323 @default.
• W852169817 cites W2252988112 @default.
• W852169817 cites W2398615553 @default.
• W852169817 hasPublicationYear "2008" @default.
• W852169817 type Work @default.
• W852169817 sameAs 852169817 @default.
• W852169817 citedByCount "0" @default.
• W852169817 crossrefType "journal-article" @default.
• W852169817 hasAuthorship W852169817A5020476147 @default.
• W852169817 hasConcept C104317684 @default.
• W852169817 hasConcept C142669718 @default.
• W852169817 hasConcept C147447768 @default.
• W852169817 hasConcept C1491633281 @default.
• W852169817 hasConcept C185592680 @default.
• W852169817 hasConcept C187436293 @default.
• W852169817 hasConcept C203014093 @default.
• W852169817 hasConcept C20418707 @default.
• W852169817 hasConcept C204232928 @default.
• W852169817 hasConcept C25602115 @default.
• W852169817 hasConcept C27740335 @default.
• W852169817 hasConcept C2778367456 @default.
• W852169817 hasConcept C2778506107 @default.
• W852169817 hasConcept C2779363559 @default.
• W852169817 hasConcept C502942594 @default.
• W852169817 hasConcept C54355233 @default.
• W852169817 hasConcept C86803240 @default.
• W852169817 hasConcept C95444343 @default.
• W852169817 hasConceptScore W852169817C104317684 @default.
• W852169817 hasConceptScore W852169817C142669718 @default.
• W852169817 hasConceptScore W852169817C147447768 @default.
• W852169817 hasConceptScore W852169817C1491633281 @default.
• W852169817 hasConceptScore W852169817C185592680 @default.
• W852169817 hasConceptScore W852169817C187436293 @default.
• W852169817 hasConceptScore W852169817C203014093 @default.
• W852169817 hasConceptScore W852169817C20418707 @default.
• W852169817 hasConceptScore W852169817C204232928 @default.
• W852169817 hasConceptScore W852169817C25602115 @default.
• W852169817 hasConceptScore W852169817C27740335 @default.
• W852169817 hasConceptScore W852169817C2778367456 @default.
• W852169817 hasConceptScore W852169817C2778506107 @default.
• W852169817 hasConceptScore W852169817C2779363559 @default.
• W852169817 hasConceptScore W852169817C502942594 @default.
• W852169817 hasConceptScore W852169817C54355233 @default.
• W852169817 hasConceptScore W852169817C86803240 @default.
• W852169817 hasConceptScore W852169817C95444343 @default.
• W852169817 hasLocation W8521698171 @default.
• W852169817 hasOpenAccess W852169817 @default.
• W852169817 hasPrimaryLocation W8521698171 @default.
• W852169817 hasRelatedWork W1966327560 @default.
• W852169817 hasRelatedWork W1992165517 @default.
• W852169817 hasRelatedWork W2016651832 @default.

• next