Matches in SemOpenAlex for { <https://semopenalex.org/work/W852445978> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W852445978 abstract "Melatonin is a neurohormone which mediates photoperiodic signals from the pineal organ to the brain. GABA (g-aminobutyric acid) is the major inhibitory transmitter in the central nervous system. It has previously been suggested that functional interaction exists between central binding sites for GABA/benzodiazepines (GABAA/bzd receptors) and melatonin in the central nervous system, and that GABA and benzodiazepines may be involved in circadian responses to light. To investigate if there is a structural basis for interactions between the neurohormone melatonin and GABA in the primary visual center, the optic tectum of the brain of the Atlantic salmon (Salmo salar) I compared the distribution of the GABAA/benzodiazepine receptor complex(GABAA/bzd receptor) to that of melatonin receptors, using immunohistochemistry (for GABAA/bzd receptors) and quantitative autoradiography (for melatonin receptors). I also investigated if there is any difference in the binding of 2-[125I]iodomelatonin at day compared to at night. I was also interested to know which transmitter substance that mediates the light-/dark message from the retina to the optic tectum via the optic tract. By using immunohistochemistry I studied the distribution of GABA in the retina and in the optic tectum. The ganglion cells in the retina showed no GABA immunoreactivity indicating that GABA is not the transmitter mediating the light-/dark message to the optic tectum. An overlap in the distribution of GABAA/bzd receptors, melatonin receptors, and GABAergic neurons and fibers in the retinorecipient layers of the optic tectum was observed. Thus, there is a structural basis for interactions between GABA and melatonin in the optic tectum of the Atlantic salmon. It is likely that GABA is involved in the intrinsic processing of the light-/dark message in the optic tectum. The 2-[125I]iodomelatonin was found to be specific, saturable, displaceable and of high affinity, with a dissociation constant (Kd) 85±14 pM and a maximum number of binding sites (Bmax) 58±7 fmol/mg protein. The Hill plot coefficient (nH) was 2.0 which indicates the presence of two types of binding sites. The presence of two binding sites could, however, not be statistically verified using MACLIGAND. No significant differences were found when comparing the 2-[125I]iodomelatonin at night to that at day." @default.
- W852445978 created "2016-06-24" @default.
- W852445978 creator A5075620408 @default.
- W852445978 date "1998-01-01" @default.
- W852445978 modified "2023-09-28" @default.
- W852445978 title "The optic tectum of the salmon:site of interaction of neurohormonal photoperiodic and neural visual signals. The GABAergic neuronal system and melatonin receptors." @default.
- W852445978 hasPublicationYear "1998" @default.
- W852445978 type Work @default.
- W852445978 sameAs 852445978 @default.
- W852445978 citedByCount "0" @default.
- W852445978 crossrefType "dissertation" @default.
- W852445978 hasAuthorship W852445978A5075620408 @default.
- W852445978 hasConcept C126322002 @default.
- W852445978 hasConcept C134018914 @default.
- W852445978 hasConcept C168258287 @default.
- W852445978 hasConcept C169760540 @default.
- W852445978 hasConcept C170493617 @default.
- W852445978 hasConcept C17077164 @default.
- W852445978 hasConcept C2776674594 @default.
- W852445978 hasConcept C2777093970 @default.
- W852445978 hasConcept C2777771985 @default.
- W852445978 hasConcept C2778182776 @default.
- W852445978 hasConcept C2779177108 @default.
- W852445978 hasConcept C2779480072 @default.
- W852445978 hasConcept C36388723 @default.
- W852445978 hasConcept C529278444 @default.
- W852445978 hasConcept C552161191 @default.
- W852445978 hasConcept C55493867 @default.
- W852445978 hasConcept C71924100 @default.
- W852445978 hasConcept C86803240 @default.
- W852445978 hasConceptScore W852445978C126322002 @default.
- W852445978 hasConceptScore W852445978C134018914 @default.
- W852445978 hasConceptScore W852445978C168258287 @default.
- W852445978 hasConceptScore W852445978C169760540 @default.
- W852445978 hasConceptScore W852445978C170493617 @default.
- W852445978 hasConceptScore W852445978C17077164 @default.
- W852445978 hasConceptScore W852445978C2776674594 @default.
- W852445978 hasConceptScore W852445978C2777093970 @default.
- W852445978 hasConceptScore W852445978C2777771985 @default.
- W852445978 hasConceptScore W852445978C2778182776 @default.
- W852445978 hasConceptScore W852445978C2779177108 @default.
- W852445978 hasConceptScore W852445978C2779480072 @default.
- W852445978 hasConceptScore W852445978C36388723 @default.
- W852445978 hasConceptScore W852445978C529278444 @default.
- W852445978 hasConceptScore W852445978C552161191 @default.
- W852445978 hasConceptScore W852445978C55493867 @default.
- W852445978 hasConceptScore W852445978C71924100 @default.
- W852445978 hasConceptScore W852445978C86803240 @default.
- W852445978 hasOpenAccess W852445978 @default.
- W852445978 hasRelatedWork W1001762143 @default.
- W852445978 hasRelatedWork W1920465582 @default.
- W852445978 hasRelatedWork W1973387213 @default.
- W852445978 hasRelatedWork W1995533386 @default.
- W852445978 hasRelatedWork W2028807464 @default.
- W852445978 hasRelatedWork W2046817740 @default.
- W852445978 hasRelatedWork W2058705672 @default.
- W852445978 hasRelatedWork W2066489680 @default.
- W852445978 hasRelatedWork W2072384636 @default.
- W852445978 hasRelatedWork W2075524775 @default.
- W852445978 hasRelatedWork W2076526475 @default.
- W852445978 hasRelatedWork W2145172383 @default.
- W852445978 hasRelatedWork W2148095461 @default.
- W852445978 hasRelatedWork W2314848516 @default.
- W852445978 hasRelatedWork W2400589599 @default.
- W852445978 hasRelatedWork W2461366060 @default.
- W852445978 hasRelatedWork W2901002348 @default.
- W852445978 hasRelatedWork W80480250 @default.
- W852445978 hasRelatedWork W954963073 @default.
- W852445978 hasRelatedWork W2783001683 @default.
- W852445978 isParatext "false" @default.
- W852445978 isRetracted "false" @default.
- W852445978 magId "852445978" @default.
- W852445978 workType "dissertation" @default.