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- W85256239 endingPage "90" @default.
- W85256239 startingPage "65" @default.
- W85256239 abstract "Recently, some of the genetic mechanisms of heart specification have been elucidated in Drosophila. This chapter summarizes the functions and interactions of genes that subdivide the early mesoderm and orchestrate the specification and initial differentiation of the Drosophila heart. In Drosophila, the formation of the mesoderm in ventral regions of blastoderm embryos is largely controlled autonomously, i.e., by mechanisms that act within the nuclei or cells that acquire mesodermal fates. Its mesoderm formation is initiated by a nuclear gradient of the maternally provided, NKkB- related morphogen Dorsal. Peak levels of nuclear Dorsal protein are present along the ventral midline of blastoderm embryos and are required to activate two zygotic genes, twist and snail, which are essential for mesoderm formation. Candidates for target genes of twist at blastoderm stage include folded gastrulation, which codes fora secreted molecule controlling aspects of mesoderm invagination; heartless, which encodes a fibroblast growth factor receptor homolog that is involved in mesoderm migration; the homeobox gene tinman that is crucial for mesoderm patterning and heart formation; mef2, which encodes a MADS domain transcription factor that functions in later aspects of muscle and heart differentiation; and zfh-1, a zinc finger- and homeobox containing gene, which is required for the differentiation of a subset of heart cells." @default.
- W85256239 created "2016-06-24" @default.
- W85256239 creator A5038705827 @default.
- W85256239 creator A5067564215 @default.
- W85256239 date "1999-01-01" @default.
- W85256239 modified "2023-10-06" @default.
- W85256239 title "Genetic Determination of Drosophila Heart Development" @default.
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