FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W85273000> ?p ?o ?g. }

• W85273000 endingPage "255" @default.
• W85273000 startingPage "243" @default.
• W85273000 abstract "The conventional signal transduction pathway for p38 MAPK is complex and diverse. A plethora of signals such as growth factors interact with death receptors to initiate a biochemical cascade by recruitment of activator molecules that in combination activate MAP3Ks. Many drugs intercede at the level of signal, activator, or MAP3Ks to mimic initiation of the signal transduction cascade. In the prostate, these signaling moieties, which include NSAIDs, converge at the level of MAP2Ks, ostensibly MKK6, which phosphorylates up to 4 isoforms of p38 MAPK. Phosphatases such as MKP1 or compounds such as biochanin A are able to antagonize activation of p38 MAPK. Phosphorylation of p38 MAPK allows phosphorylation of MK2 and MK3 that in turn promote stability of the p75NTR transcript. Concurrently, translocation of HuR from the nucleus to the cytoplasm and increased levels of HuR and eIF4E also promote p75NTR mRNA stability and increased levels of the p75NTR protein. In the prostate, the p75NTR functions as both a tumor and metastasis suppressor. In this context, increased expression of p75NTR modulates cell cycle effectors producing cytostasis in G0/G1, as well as mitochondrial effectors that modulate a caspase cascade leading to apoptosis. In addition, increased expression of p75NTR modulates motility effectors, ostensibly NAG-1, that retards cell migration. Hence, activation of the p38 MAPK pathway through a plethora of signal initiating events, leads to tumor and metastasis suppressor activity in prostate cancer cells.KeywordsProstate Cancer CellInhibit Cell MigrationReduce Cell Migrationp75NTR ExpressionInitiate Signal TransductionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W85273000 created "2016-06-24" @default.
• W85273000 creator A5004891366 @default.
• W85273000 date "2013-01-01" @default.
• W85273000 modified "2023-09-23" @default.
• W85273000 title "The p38 MAPK Pathway in Prostate Cancer" @default.
• W85273000 cites W1555692789 @default.
• W85273000 cites W1556080027 @default.
• W85273000 cites W1572772426 @default.
• W85273000 cites W1972304405 @default.
• W85273000 cites W1976385326 @default.
• W85273000 cites W1976462601 @default.
• W85273000 cites W1979196115 @default.
• W85273000 cites W1980360982 @default.
• W85273000 cites W1980605560 @default.
• W85273000 cites W1981213398 @default.
• W85273000 cites W1981860646 @default.
• W85273000 cites W1986010882 @default.
• W85273000 cites W1987704983 @default.
• W85273000 cites W1990073151 @default.
• W85273000 cites W1992930337 @default.
• W85273000 cites W2004551257 @default.
• W85273000 cites W2009880140 @default.
• W85273000 cites W2013911798 @default.
• W85273000 cites W2016792778 @default.
• W85273000 cites W2017682357 @default.
• W85273000 cites W2018342349 @default.
• W85273000 cites W2022233291 @default.
• W85273000 cites W2028041910 @default.
• W85273000 cites W2028184386 @default.
• W85273000 cites W2030900078 @default.
• W85273000 cites W2031744617 @default.
• W85273000 cites W2032731042 @default.
• W85273000 cites W2034425544 @default.
• W85273000 cites W2035477425 @default.
• W85273000 cites W2040169548 @default.
• W85273000 cites W2049204919 @default.
• W85273000 cites W2057062872 @default.
• W85273000 cites W2057782598 @default.
• W85273000 cites W2062289724 @default.
• W85273000 cites W2064026653 @default.
• W85273000 cites W2066008440 @default.
• W85273000 cites W2074616119 @default.
• W85273000 cites W2075614333 @default.
• W85273000 cites W2078142614 @default.
• W85273000 cites W2079749507 @default.
• W85273000 cites W2081130105 @default.
• W85273000 cites W2081633731 @default.
• W85273000 cites W2083210944 @default.
• W85273000 cites W2084296544 @default.
• W85273000 cites W2084472730 @default.
• W85273000 cites W2088764696 @default.
• W85273000 cites W2097644162 @default.
• W85273000 cites W2100438302 @default.
• W85273000 cites W2101821836 @default.
• W85273000 cites W2106599502 @default.
• W85273000 cites W2107495112 @default.
• W85273000 cites W2108883732 @default.
• W85273000 cites W2112179971 @default.
• W85273000 cites W2114471642 @default.
• W85273000 cites W2119275519 @default.
• W85273000 cites W2122057254 @default.
• W85273000 cites W2127551467 @default.
• W85273000 cites W2136880181 @default.
• W85273000 cites W2142848667 @default.
• W85273000 cites W2148687850 @default.
• W85273000 cites W2150110393 @default.
• W85273000 cites W2150192479 @default.
• W85273000 cites W2152393285 @default.
• W85273000 cites W2152476041 @default.
• W85273000 cites W2152616419 @default.
• W85273000 cites W2158455388 @default.
• W85273000 cites W2164600251 @default.
• W85273000 cites W2165474698 @default.
• W85273000 cites W2325880234 @default.
• W85273000 cites W2404013489 @default.
• W85273000 doi "https://doi.org/10.1007/978-1-4614-6828-8_8" @default.
• W85273000 hasPublicationYear "2013" @default.
• W85273000 type Work @default.
• W85273000 sameAs 85273000 @default.
• W85273000 citedByCount "2" @default.
• W85273000 countsByYear W852730002015 @default.
• W85273000 countsByYear W852730002022 @default.
• W85273000 crossrefType "book-chapter" @default.
• W85273000 hasAuthorship W85273000A5004891366 @default.
• W85273000 hasBestOaLocation W852730001 @default.
• W85273000 hasConcept C11960822 @default.
• W85273000 hasConcept C170493617 @default.
• W85273000 hasConcept C502942594 @default.
• W85273000 hasConcept C51551487 @default.
• W85273000 hasConcept C55493867 @default.
• W85273000 hasConcept C57074206 @default.
• W85273000 hasConcept C62478195 @default.
• W85273000 hasConcept C86803240 @default.
• W85273000 hasConcept C88045685 @default.
• W85273000 hasConcept C95444343 @default.
• W85273000 hasConceptScore W85273000C11960822 @default.
• W85273000 hasConceptScore W85273000C170493617 @default.

• next