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• W852760478 abstract "This chapter discusses one's current knowledge of the properties of mitochondrial antiviral signaling (MAVS), its role in signaling, as well as its role in the in vivo host response to infection with RNA viruses. MAVS was discovered independently by four different groups, and so it is also called IPS-1, VISA, and Cardif. Importantly, the mitochondrial localization of MAVS is critical for it to induce interferons I (IFN-I). The chapter provides a more detailed description of tumor receptor associated factor (TRAF) and their role in the retinoic acid-inducible gene I (RIG-I)/melanoma differentiation associated gene 5 (MDA-5) pathway. The mitochondrial localization of MAVS is crucial for antiviral signaling because removal of the C-terminal mitochondrial targeting domain (TM) of MAVS abolishes its ability to induce IFNs. The chapter summarizes the current knowledge of MAVS signaling, and points out some outstanding questions that demand further dissection. In summary, an outline that emerges from the recent studies is that MAVS activates IKB kinase (IKK) and TBK1 through TRAF proteins as well as several kinase adaptors. To date, two studies have examined the activation of adaptive immune parameters in MAVS-/- mice. It is now well established that MAVS serves as an essential signaling adaptor in the cytosolic antiviral signaling pathway." @default.
• W852760478 created "2016-06-24" @default.
• W852760478 creator A5000591490 @default.
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• W852760478 date "2014-04-09" @default.
• W852760478 modified "2023-09-26" @default.
• W852760478 title "Mitochondrial Antiviral Signaling" @default.
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• W852760478 doi "https://doi.org/10.1128/9781555815561.ch4" @default.
• W852760478 hasPublicationYear "2014" @default.
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