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- W85276585 abstract "Progenitorcellsthatexpressthetranscriptionfactorolig1generateseveralneuralcelltypesincludingoligodendrocytesandGABAergic interneurons in the dorsal cortex. The fate of these progenitor cells is regulated by a number of signals including bone morphogenetic proteins (BMPs) secreted in the dorsal forebrain. BMPs signal by binding to heteromeric serine‐threonine kinase receptors formed by type I (BMPR1a, BMPR1b, Alk2) and type II (BMPRII) subunits. To determine the specific role of the BMPR1a subunit in lineage commitmentbyolig1-expressingcells,weusedacre/loxPgeneticapproachtoablateBMPR1ainthesecellswhileleavingsignalingfrom other subunits intact. There was a reduction in numbers of immature oligodendrocytes in the BMPR1a-null mutant brains at birth. However,bypostnatalday20,theBMPR1a-nullmicehadasignificantincreaseinthenumberofmatureandimmatureoligodendrocytes comparedwithwild-typelittermates.Therewasalsoanincreaseintheproportionofcalbindin-positiveinterneuronsinthedorsomedial cortex of BMPR1a-null mice at birth without any change in the number of parvalbumin- or calretinin-positive cells. These effects were attributable,atleastinpart,toadecreaseinthelengthofthecellcycleinsubventricularzoneprogenitorcells.Thus,ourfindingsindicate that BMPR1a mediates the suppressive effects of BMP signaling on oligodendrocyte lineage commitment and on the specification of calbindin-positiveinterneuronsinthedorsomedialcortex." @default.
- W85276585 created "2016-06-24" @default.
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- W85276585 date "2007-01-01" @default.
- W85276585 modified "2023-09-27" @default.
- W85276585 title "BMPR1aSignalingDeterminesNumbersof OligodendrocytesandCalbindin-ExpressingInterneuronsin theCortex" @default.
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