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- W853329076 abstract "Recent researches demonstrate that onset of cerebral infarction always accompanies with obvious changes of function of thyroid axis; while, high-homocysteic acidemia has been proved as one of risk factors of vascular dementia and Alzheimer disease. Meanwhile, it is found that level of plasma homocysteic acid is positive correlation with injured degrees of cognitive function and brain damage.OBJECTIVE: To observe the changes of function of thyroid and level of homocysteic acid among patients with vascular dementia and compare with those patients without dementia cerebral infarction.DESIGN: Randomized grouping and contrast observation.SETTING: Department of Neurology, People's Hospital Affiliated to Yunyang Medical College, South China Hospital of Wuhan University.PARTICIPANTS: A total of 38 patients with vascular dementia were hospitalized in the Department of Neurology, People's Hospital Affiliated to Yunyang Medical College from February 2004 to December 2005. All patients met the diagnostic criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorder(DSM-IV) established by American Psychiatric Association. Based on educational degrees, Mini-mental Status Examination (MMSE) was classified into illiteracy (≤ 17 points), education of primary school (educational duration ≤ 6 years, ≤ 24 points) and education of middle school or above (educational duration ＞ 6 years, ≤24 points). Forty patients with non-dementia cerebral infarction were regarded as the control group and checked with CT examination. There were no significant differences of sex and age between the two groups.All patients and relatives were provided the consent.METHODS: Within 24 hours after hospitalization, patients with vascular dementia received MMSE scores, and the degrees were classified based on the scoring results: mild (20-24 points), moderate (10-19 points) and severe (below 10 points). Levels of thyroxine were measured with radioimmunodetection and content of homocysteic acid was measured with high perform" @default.
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- W853329076 date "2006-01-01" @default.
- W853329076 modified "2023-09-24" @default.
- W853329076 title "Combined measurement of thyroid and plasma homocysteic acid for detecting the severity of vascular dementia" @default.
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