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- W853467 abstract "A rational systematic evaluation is essential to the management of a couple with repeated early pregnancy wastage. Psychologic support in the form of frequent discussions and sympathetic counseling are crucial to the successful evaluation and treatment of the anxious couple. A prompt and orderly evaluation will relieve anxiety. When no etiologic factor is identified, a 60% to 80% fetal salvage rate may be expected. Once a patient conceives, serial ultrasonography, beta-hCG determination, and estradiol determination may be useful in detecting the stage of the embryonic death if subsequent abortion occurs. A karyotypic analysis of the products of conception should be performed if fetal loss occurs.This review of the current literature on the clinical management of repeated early pregnancy wastage focuses on several etiologic factors (i.e., genetic, medical, immunologic, endocrine, psychogenic, environmental, occupational, infectious, and uterine) which have been noted to result in repeated pregnancy wastage. Suggestions for further clinical study are outlined where appropriate, and a rational approach to clinical evaluation and management is provided, based on the interpretation of the state of the art. The frequency of clinically recognized spontaneous abortion in the general population has been estimated to range between 15-20%. The actual spontaneous abortion rate is difficult to determine due to the fact that some patients do not seek medical services and abort completely at home. Despite the present uncertainty concerning the actual risk of recurrent abortion, most clinicians agree that repeated early spontaneous pregnancy wastage (i.e., repeated pregnancy loss) is defined as the occurrence of 3 or more pregnancy losses prior to the 20th week of gestation. From cytogenetic studies of aborted products of conception, chromosomal abnormalities account for between 50-60% of spontaneous abortions in the 1st trimester of pregnancy. Most of the chromosomal aberrations involved in spontaneous abortions have been presumed to be due to random events that are not necessarily repetitious. Sporadic chromosomal errors account for approximately 30% of spontaneous pregnancy losses, and repeated pregnancy loss under these conditions would therefore occur as a matter of chance and would not be predictive of future pregnancy loss. Several medical diseases have been implicated in causing habitual abortion, and these include systemic lupus erythematosus, congenital cardiac disease, and renal disease. The severity of the disease correlates best with fetal wastage. An absence of blocking antibodies within the serum of women with repeated abortions was reported by Rocklin et al. A review of the literature shows that only an association exists between psychologic disturbances and habitual abortion. Intrauterine infection may result in early pregnancy wastage, and fetal death may result from an acute overwhelming infection. It has long been recognized that congenital anomalies of the uterus have been responsible in some instances for reproductive failure. The gynecologist must consider the time of initiation of an evaluation of a patient with reproductive loss. Any evaluation must include a complete history and a karyotypic analysis with fluorescent banding of both partners, a hysterogram, and a properly timed endometrial biopsy. In the authors' experience, about 50% of patients with repeated pregnancy loss have no discernible etiologic factor. Subsequent early pregnancy should be carefully monitored in these patients. When no etiologic factor is identfied, a 60-80% fetal salvage rate may be expected." @default.
- W853467 created "2016-06-24" @default.
- W853467 creator A5006695239 @default.
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- W853467 date "1983-02-01" @default.
- W853467 modified "2023-10-06" @default.
- W853467 title "The clinical management of repeated early pregnancy wastage" @default.
- W853467 cites W1015547071 @default.
- W853467 cites W119054975 @default.
- W853467 cites W1489401194 @default.
- W853467 cites W1495847395 @default.
- W853467 cites W1506675329 @default.
- W853467 cites W1508965644 @default.
- W853467 cites W1517218657 @default.
- W853467 cites W1528877757 @default.
- W853467 cites W1529247505 @default.
- W853467 cites W157431151 @default.
- W853467 cites W1589259293 @default.
- W853467 cites W1595892421 @default.
- W853467 cites W1686534556 @default.
- W853467 cites W170728788 @default.
- W853467 cites W176294935 @default.
- W853467 cites W179316176 @default.
- W853467 cites W1805331424 @default.
- W853467 cites W181561894 @default.
- W853467 cites W1927588290 @default.
- W853467 cites W1965095108 @default.
- W853467 cites W1968232306 @default.
- W853467 cites W1973611632 @default.
- W853467 cites W1983739322 @default.
- W853467 cites W1987001383 @default.
- W853467 cites W1987772994 @default.
- W853467 cites W1989451035 @default.
- W853467 cites W1989803373 @default.
- W853467 cites W1993030940 @default.
- W853467 cites W2002641760 @default.
- W853467 cites W2009200889 @default.
- W853467 cites W2014946175 @default.
- W853467 cites W2017141381 @default.
- W853467 cites W2020246941 @default.
- W853467 cites W2023251081 @default.
- W853467 cites W2024660667 @default.
- W853467 cites W2026941190 @default.
- W853467 cites W2027344840 @default.
- W853467 cites W2041862373 @default.
- W853467 cites W2043475780 @default.
- W853467 cites W2044390886 @default.
- W853467 cites W2044878375 @default.
- W853467 cites W2053201774 @default.
- W853467 cites W2054069394 @default.
- W853467 cites W2059511233 @default.
- W853467 cites W2066788026 @default.
- W853467 cites W2067722817 @default.
- W853467 cites W2069421192 @default.
- W853467 cites W2072862194 @default.
- W853467 cites W2078176111 @default.
- W853467 cites W2078753269 @default.
- W853467 cites W2078942664 @default.
- W853467 cites W2082779277 @default.
- W853467 cites W2083075266 @default.
- W853467 cites W2083166228 @default.
- W853467 cites W2088934456 @default.
- W853467 cites W2093680958 @default.
- W853467 cites W2104318350 @default.
- W853467 cites W2125883068 @default.
- W853467 cites W2130055600 @default.
- W853467 cites W2153364723 @default.
- W853467 cites W2168035946 @default.
- W853467 cites W2169822481 @default.
- W853467 cites W2221700129 @default.
- W853467 cites W2264069562 @default.
- W853467 cites W2302344012 @default.
- W853467 cites W2314570011 @default.
- W853467 cites W2321159927 @default.
- W853467 cites W2321533542 @default.
- W853467 cites W2326592355 @default.
- W853467 cites W2330024077 @default.
- W853467 cites W2336104393 @default.
- W853467 cites W2336575980 @default.
- W853467 cites W2340600873 @default.
- W853467 cites W2341965668 @default.
- W853467 cites W2346586293 @default.
- W853467 cites W2346674611 @default.
- W853467 cites W2394651527 @default.
- W853467 cites W2395438031 @default.
- W853467 cites W2398492825 @default.
- W853467 cites W2401571595 @default.
- W853467 cites W2402889424 @default.
- W853467 cites W2407184176 @default.
- W853467 cites W2410822634 @default.
- W853467 cites W2411257169 @default.
- W853467 cites W2411825897 @default.
- W853467 cites W2411884838 @default.
- W853467 cites W2412495146 @default.
- W853467 cites W2414859593 @default.
- W853467 cites W2416449527 @default.
- W853467 cites W2417187577 @default.