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- W853500695 abstract "Introduction: Obesity in childhood is associated with an increased prevalence of diabetes and other traditional cardiometabolic risk factors, suggesting an epidemic of premature cardiovascular disease among today’s youth. Glycotoxins, known as advanced glycation end products (AGE’s), activating via the membrane-bound receptors (mRAGE), have been implicated in the pathophysiology of inflammation, (increased tumor necrosis factorα [TNFα ]), insulin resistance and vascular dysfunction in adults, but the role of RAGE in the early stages of metabolic disorders is unknown. In this study, we assessed relationship of cardiometabolic risk factors, mRNA expression of TNFα and RAGE in peripheral monocytes in adolescents with obesity. Methods: Thirty three adolescents,11-16 years of age, with body mass index (BMI) Z-score≥2 were admitted following a 12-hour overnight fast for anthropometrics, lipid profile , fasting peripheral blood sample collection, and a 2-hour 75 gm, oral glucose tolerance test (OGTT). Peripheral blood mononuclear cells (PBMNC) positive for CD14 were isolated from blood. Cells were further analyzed by quantitative PCR for mRNA expression of RAGE and TNF-α. Pearson's coefficients were calculated to assess the associations between RAGE mRNA and cardiometabolic risk factors as well as TNFα mRNA levels. Results: The participants had a mean age of 12.7±1.41 years and BMIZ score 2.32±0.35 SD with 81 % participants being female; 62 % were Black, 28% Caucasian, 10% were Hispanic. We observed a positive correlation between mRNA levels of RAGE and TNFα in CD14+ monocytes in blood (r=0.62, p<0.01). However, we did not observe a correlation of BMI, cholesterol or triglyceride with RAGE mRNA levels. Conclusion: The positive relationship between the monocyte mRNA levels of RAGE and TNF-α suggest involvement of AGERAGE axis in obesity-associated inflammation and needs to be further investigated with larger sample size as well as studies in healthy adolescents." @default.
- W853500695 created "2016-06-24" @default.
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- W853500695 date "2014-01-01" @default.
- W853500695 modified "2023-09-23" @default.
- W853500695 title "Receptor of Advanced Glycation Endproducts (RAGE) is Positively Correlated with Tumor Necrosis Factor-α in Adolescents with Obesity" @default.
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