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- W853754140 endingPage "668" @default.
- W853754140 startingPage "601" @default.
- W853754140 abstract "Publisher Summary Control of T. cruzi infection requires the activation of multiple immune effector mechanisms in relation to the presence of both extracellular trypomastigotes and intracellular amastigotes. Protection is mainly governed by IFNs (initially type 1 IFNs, then IFN-γ). However, it is worth noting that neutrophils and iNKT cells seem to have an important role in the very initial steps of the infection, without forgetting the essential contribution of NK cells and macrophages later on. The parasite has evolved an impressive number of mechanisms allowing it to establish slowly as well as to escape such complex immune response. Its ability is to temporarily limit Ag presentation through MHC class I molecules and to favor the release of amastigotes that invade preferentially unactivated macrophages in particular. Actually, the parasite is most generally on the winning side, as the host does not reach eliminating it. Thus, T. cruzi seems to be a real magician that adapts to many adverse situations. To date it is not known why the host does not reach eliminating the parasite and remains lifelong infected. Late chronic infection in humans is associated with the progressive disappearance of early-activated T cells and waning of T cell responses, atleast in the absence of reinfections. The underlying mechanisms should be addressed, keeping in mind that it remains to know if the host would actually benefit from a better efficient immune response in the long term, since it might have pathological consequences in some chronically infected individuals." @default.
- W853754140 created "2016-06-24" @default.
- W853754140 creator A5025854394 @default.
- W853754140 creator A5067378842 @default.
- W853754140 creator A5073168085 @default.
- W853754140 creator A5091905349 @default.
- W853754140 date "2010-01-01" @default.
- W853754140 modified "2023-10-17" @default.
- W853754140 title "Protective Host Response to Parasite and Its Limitations" @default.
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