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- W85390982 abstract "Twenty patients with mixed hyperlipidemia type IIb were treated for two weeks with the lipid lowering agent gemfibrozil at a dose of 900 mg/day. The mean age of the 10 younger ambulatory patients was 32.3 +/- 4.1 years, that of the 10 geriatric inpatients 76.9 +/- 7.1 years. Fasting blood samples were drawn from the patients on days 1, 7 and 14, and plasma lipids and apolipoproteins determined. In addition, the plasma phospholipids were isolated and the fatty acid composition determined by gas chromatography.After only two weeks treatment with gemfibrozil, triglyceride and phospholipid plasma levels were significantly decreased. The therapeutic effects were more pronounced in the elderly patients, mainly female and most with diabetes mellitus, than in the younger, predominantly male hyperlipidemic patients. In accordance with the mechanism of action of gemfibrozil, the initially pathologically elevated levels of plasma free fatty acids in the geriatrics returned to normal. Furthermore, the fraction of long chain saturated fatty acids among the phospholipids became smaller, suggesting an impairment of chain elongation of fatty acids in the hepatic microsomes." @default.
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- W85390982 date "1996-05-10" @default.
- W85390982 modified "2023-09-26" @default.
- W85390982 title "[Gemfibrozil in the elderly. Effects on lipid metabolism]." @default.
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