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- W854045634 abstract "[Objective] To analysis the structure of human Apobec-1 gene and its protein, and to predict the physicochemical property and the physiologic function.[Methods] We searched the website of NCBI and SWISS-PROT;Clustal X computer program was used to obtain the multisequence homology alignment among Apobec-1 and similar proteins, and estab-lish the cladogram observed with TreeView computer program;The model of spatial structure was checked by Cn3D computer program.[Results](1) The human Apobec-1 gene was localized in 12P13.1, was 18kb length, and contained 5 exons;(2) The transcript of holo-gene was 236aa, open reading frame was 191aa, three sites of NO.61, 93 and 96 in polypeptide chain could combine with Zn2+, and there were 14 conserved leucine residues in the carboxy-terminal region;(3) The molecular weight of Apobec-1 was 28 173.54, the isoelectric point was 9.06, the half-life period was 30h, the hydrophobicity was at the range of 2.222-4.667, belonged to intra-cellular protein, and contained 7 transmembrane domains and 16 trypsiniza-tional fragments.Apobec-1 could only be detected in colon and rectum of adult normal(﹥17y), while leukemic cells could express it in pathologic status;(4) Apobec-1 could encode the first base of codon 2153 glutamine of CAA to termination codon UAA, so that to create encoded mRNA of ApoB48.The Apobec-1 had the activity of cytidine deaminase, hydrolase and zinc ion binding.[Conclusion] The physico-chemical property and the physiologic function of the human Apobec-1 can be predicted through the structure of gene and its protein by the method of bioinformatics, which provide theoretic basis for correlative re-searches." @default.
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- W854045634 date "2009-01-01" @default.
- W854045634 modified "2023-09-24" @default.
- W854045634 title "Bioinformatical analysis of the human apob editing catalytic polypeptide-1." @default.
- W854045634 hasPublicationYear "2009" @default.
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