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- W8541401 abstract "Research Article1 November 1988free access Genomic organization of the human oestrogen receptor gene. M. Ponglikitmongkol M. Ponglikitmongkol Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author S. Green S. Green Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author P. Chambon P. Chambon Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author M. Ponglikitmongkol M. Ponglikitmongkol Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author S. Green S. Green Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author P. Chambon P. Chambon Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. Search for more papers by this author Author Information M. Ponglikitmongkol1, S. Green1 and P. Chambon1 1Laboratoire de Génétique Moléculaire, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France. The EMBO Journal (1988)7:3385-3388https://doi.org/10.1002/j.1460-2075.1988.tb03211.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The oestrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. We show here that the human ER gene is greater than 140 kb in length, split into eight exons and that the positions of these introns have been highly conserved when compared with the chicken progesterone receptor and are remarkably similar to those of one of the chicken thyroid hormone receptor genes. The N-terminal A/B region, which is not conserved between the different members of the nuclear receptor family, is almost entirely encoded within a single exon. Notably each of the putative ‘zinc fingers’ of the receptor DNA-binding domain is encoded separately, and the hormone-binding domain is assembled from five exons. In addition, we find that the ER isolated from the human breast cancer cell line MCF-7 contains a Gly-400––Val mutation present in the hormone-binding domain. Previous ArticleNext Article Volume 7Issue 111 November 1988In this issue RelatedDetailsLoading ..." @default.
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- W8541401 title "Genomic organization of the human oestrogen receptor gene." @default.
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