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- W854338575 abstract "This thesis investigates the development of sensing devices based on molecularlyimprinted polymers for the detection of clinically relevant analytes. Three analyteswere considered, metronidazole, creatinine and propofol.A molecularly imprinted polymer (MIP) was computationally designed formetronidazole and tested using SPE techniques. This polymer was then grafted onto atransducer surface using an immobilised initiator. Amperometric and impedancedetection of metronidazole were investigated.The capacitive detection of creatinine was reproduced from the literature (Panasyuk-Delaney et al., 2002) as this approach could be applied to other MIPs to form auniversal platform for sensor development. However, the sensors produced using thismethodology were difficult to reproduce and attempts to improve them wereunsuccessful. A model for capacitive electrodes was developed to explain the obtainedresults.To address the key challenges found in the aforementioned work, a dual polymerisablemonomer was used as a conductive anchor for the amperometric and impedancedetection of propofol. The developed amperometric sensors demonstrated very highsensitivity (limit of detection was below 5 µM), although the electrodes lacked inselectivity.In conclusion, this thesis illustrates some of the key areas which need to be consideredin the development of MIP-based devices and investigates some innovative solutions tothese problems." @default.
- W854338575 created "2016-06-24" @default.
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- W854338575 date "2009-01-01" @default.
- W854338575 modified "2023-09-27" @default.
- W854338575 title "Development of sensors for the detection of clinically relevant substances using molecular imprinting" @default.
- W854338575 hasPublicationYear "2009" @default.
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