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- W854404791 abstract "Publisher Summary This chapter discusses the sequential degradation of peptides and proteins from their COOH termini with ammonium thiocyanate and acetic anhydride. It is shown that degradations of two peptides derived from insulin and ribonuelease. To ensure that the cyclization reaction is complete, the conditions used for peptides are more extreme than those required for complete reaction of small model compounds, such as acetyl amino acids. The extent of conversion of the COOH-terminal valine of ribo-nuclease into a thiohydantoin is found to be essentially quantitative under the conditions tested. Proline and aspartic acid are not degraded when they occur at the COOH terminus. The recent finding that dithioerythritol is extremely effective in protecting phenylthiohydantoins from oxidative desulfuration, suggests that inclusion of this compound in solvents for separation of thiohydantoins will improve recoveries greatly and perhaps even make possible the use of the method for quantitative estimation of protein COOH termini." @default.
- W854404791 created "2016-06-24" @default.
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- W854404791 date "1972-01-01" @default.
- W854404791 modified "2023-10-14" @default.
- W854404791 title "[29] Sequential degradation of peptides and proteins from their COOH termini with ammonium thiocyanate and acetic anhydride" @default.
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- W854404791 doi "https://doi.org/10.1016/s0076-6879(72)25032-7" @default.
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